期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Au,Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration 被引量:3
1
作者 Giovanna Calabrese Salvatore Petralia +7 位作者 Claudia Fabbi stefano forte Domenico Franco Salvatore Guglielmino Emanuela Esposito Salvatore Cuzzocrea Francesco Traina Sabrina Conoci 《Regenerative Biomaterials》 SCIE 2020年第5期461-469,共9页
Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTE)allowing the incorporation of nanomaterials able to improve cell proliferation and differentiation.In this stu... Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTE)allowing the incorporation of nanomaterials able to improve cell proliferation and differentiation.In this study,Mg-HA-Coll type I scaffolds(Mg-HA-based scaffolds)were nanofunctionalized with gold nanorods(Au NRs),palladium nanoparticles(Pd NPs)and maghemite nanoparticles(MAG NPs).Nanofunctionalized Mg-HA-based scaffolds(NF-HA-Ss)were tested for their ability to promote both the proliferation and the differentiation of adipose-derived mesenchymal stem cells(hADSCs).Results clearly highlight that MAG nanofunctionalization substantially improves cell proliferation up to 70% compared with the control(Mg-HA-based scaffold),whereas both Au NRs and Pd NPs nanofunctionalization induce a cell growth inhibition of 94% and 89%,respectively.Similar evidences were found for the osteoinductive properties showing relevant calcium deposits(25% higher than the control)for MAG nanofunctionalization,while a decreasing of cell differentiation(20% lower than the control)for both Au NRs and Pd NPs derivatization.These results are in agreement with previous studies that found cytotoxic effects for both Pd NPs and Au NRs.The excellent improvement of both osteoconductivity and osteoinductivity of the MAG NF-HA-S could be attributed to the high intrinsic magnetic field of superparamagnetic MAG NPs.These findings may pave the way for the development of innovative nanostructured scaffolds for BTE. 展开更多
关键词 bone regeneration hydroxyapatite scaffold tissue engineering gold nanoroads Pd nanoparticles maghemite nanoparticles
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部