Objective:Arginine methylation is a common posttranslational modification that plays pivotal roles in signal transduction.However,its function in human diseases is poorly understood.Protein methyltransferase 6(PRMT6)b...Objective:Arginine methylation is a common posttranslational modification that plays pivotal roles in signal transduction.However,its function in human diseases is poorly understood.Protein methyltransferase 6(PRMT6)belongs to the type I PRMT enzyme family,responsible for catalyzing the asymmetric dimethylation of arginine residues in proteins.展开更多
The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating ev...The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications.展开更多
文摘Objective:Arginine methylation is a common posttranslational modification that plays pivotal roles in signal transduction.However,its function in human diseases is poorly understood.Protein methyltransferase 6(PRMT6)belongs to the type I PRMT enzyme family,responsible for catalyzing the asymmetric dimethylation of arginine residues in proteins.
基金supported by grants from the Research Grant Council-General Research Fund (HKU 760911M and HKU 773412M)Research Grant Council-Collaborative Research Fund (CUHK8/CRF/11R, HKU3/ CRF/11R and HKU7/CRF/09)the University of Hong Kong Strategic Research Theme in Cancer
文摘The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications.
