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Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria
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作者 stephen Tukwasibwe Annettee Nakimuli +8 位作者 James Traherne Olympe Chazara Jyothi Jayaraman John Trowsdale Ashley Moffett Prasanna Jagannathan Philip JRosenthal stephen cose Francesco Colucci 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2020年第8期799-806,共8页
Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is lik... Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection. These functions are modulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs). Therefore, variations in KIR and HLA genes can have a direct impact on NK cell functions. Understanding the role of KIRs and HLAs in immunity to malaria can help to better characterize antimalarial immune responses. In this review, we summarize the different KIRs and HLAs associated with immunity to malaria thus far. 展开更多
关键词 Genetic variation Human Leukocyte Antigen Innate immunity Killer-cell immunoglobulin-like receptor MALARIA Natural killer cells
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