Plants toxic to livestock species have a significantly negative impact on agriculture but can be an important source of bioactive molecules for use in medicine.The initial research on plant toxicity is focused on the ...Plants toxic to livestock species have a significantly negative impact on agriculture but can be an important source of bioactive molecules for use in medicine.The initial research on plant toxicity is focused on the response to the poisoning and the specific livestock species impacted by the toxic plant.This research emphasizes the identification of the plant and natural product(s)responsible for the toxicity to livestock,the prevention of further poisonings,and the development of treatments for the affected animals.Once the bioactive molecules impacting the livestock species have been identified,research on these compounds is then focused on determining the mechanism of action,the development of models for further study,and the identification of potential drug candidates for the treatment of disease.Specific examples of the agricultural-based research that are relevant to Human and Veterinary Medicine include:cyclopamine from Veratrum californicum(western false hellebore),piperidine alkaloids fromLupinus species(lupines),and cicutoxin from Cicuta species(water hemlock).展开更多
Introduction Thltreport review*ourrecentexperienceofImplentatlon of me newer generation Implentsble cerdloverter-deflbrlllator (ICD) in two (ooal cardiology oantnis.Pram January 1998, 11 patients (0 mete, maan aga ...Introduction Thltreport review*ourrecentexperienceofImplentatlon of me newer generation Implentsble cerdloverter-deflbrlllator (ICD) in two (ooal cardiology oantnis.Pram January 1998, 11 patients (0 mete, maan aga 80.8 yeira) received iCOe. 6 had dilated cardtomyopathy, 4 feohamic heart disease and 2 hypertrophlc cardlomyopathy. The presentations war* palpitations with documented ventricular tachycardia or ventricular flfriflatfon (VT/VF) (n fl). non-sustained VT (N 3) and history of unexplained recurrent syncope (n*1). All patlenta had etoctrophyvloloQtcal atudles (ventrlculer tachycardia tndudble In 8. ventricular flutter In 2. One patient who presented with non- utta(ned vT and recurrent synoopa and Indudble ventricular flutter wa treated directly with ICD Implant without prior madteatlonr Tha r malnln0 10 oetei had felled medloal treatment Tha prooadure w § carriad out In the cardiac catheterizatlen laboratory under con*cloir tadatlon and local anaestheele. All patlentt tolerated the prooadura wall. &ubmu cuiar Impfantatlon was performed In a and aubcuteneout In 3. Slnplo lead ICD wltti algorithm for supraventrioulerteohycardle discrimination were used In 10 patients end duet chamber ICO was Implanted in 1. The precedura was uncomplicated In all petlents. All patients had a deflbrillatlon threshold testing (DFT) of more then 10J safety margin. All patlenta ware re-examined one day liter the procedure on their recapitulation of the procedure and assessment with coring system over prosanoo of mnolB, recall of the procedure and the severity of pain during dft testing. Upon a mean follow-up of 1 to 8 months, there was appropriate shocks In 4, recognition of atrial arrhythmia In 1 {with the dual chamber ICD) wtth no therapy given. There were 2 Inappropriate shocks but upon reprognsmmlng or the SVT dliorlm’naBon algorithm, thera was no recurrence,Conclusion : Newer generation pectoral (CDs with its smalter alee end SVT discrimination algorithm have significant adventage over the older generations ICD In that they could be Implanted under local anaesthesia with less patient discomfort and have a low Incidence of Inappropriate ahooke.展开更多
文摘Plants toxic to livestock species have a significantly negative impact on agriculture but can be an important source of bioactive molecules for use in medicine.The initial research on plant toxicity is focused on the response to the poisoning and the specific livestock species impacted by the toxic plant.This research emphasizes the identification of the plant and natural product(s)responsible for the toxicity to livestock,the prevention of further poisonings,and the development of treatments for the affected animals.Once the bioactive molecules impacting the livestock species have been identified,research on these compounds is then focused on determining the mechanism of action,the development of models for further study,and the identification of potential drug candidates for the treatment of disease.Specific examples of the agricultural-based research that are relevant to Human and Veterinary Medicine include:cyclopamine from Veratrum californicum(western false hellebore),piperidine alkaloids fromLupinus species(lupines),and cicutoxin from Cicuta species(water hemlock).
文摘Introduction Thltreport review*ourrecentexperienceofImplentatlon of me newer generation Implentsble cerdloverter-deflbrlllator (ICD) in two (ooal cardiology oantnis.Pram January 1998, 11 patients (0 mete, maan aga 80.8 yeira) received iCOe. 6 had dilated cardtomyopathy, 4 feohamic heart disease and 2 hypertrophlc cardlomyopathy. The presentations war* palpitations with documented ventricular tachycardia or ventricular flfriflatfon (VT/VF) (n fl). non-sustained VT (N 3) and history of unexplained recurrent syncope (n*1). All patlenta had etoctrophyvloloQtcal atudles (ventrlculer tachycardia tndudble In 8. ventricular flutter In 2. One patient who presented with non- utta(ned vT and recurrent synoopa and Indudble ventricular flutter wa treated directly with ICD Implant without prior madteatlonr Tha r malnln0 10 oetei had felled medloal treatment Tha prooadure w § carriad out In the cardiac catheterizatlen laboratory under con*cloir tadatlon and local anaestheele. All patlentt tolerated the prooadura wall. &ubmu cuiar Impfantatlon was performed In a and aubcuteneout In 3. Slnplo lead ICD wltti algorithm for supraventrioulerteohycardle discrimination were used In 10 patients end duet chamber ICO was Implanted in 1. The precedura was uncomplicated In all petlents. All patients had a deflbrillatlon threshold testing (DFT) of more then 10J safety margin. All patlenta ware re-examined one day liter the procedure on their recapitulation of the procedure and assessment with coring system over prosanoo of mnolB, recall of the procedure and the severity of pain during dft testing. Upon a mean follow-up of 1 to 8 months, there was appropriate shocks In 4, recognition of atrial arrhythmia In 1 {with the dual chamber ICD) wtth no therapy given. There were 2 Inappropriate shocks but upon reprognsmmlng or the SVT dliorlm’naBon algorithm, thera was no recurrence,Conclusion : Newer generation pectoral (CDs with its smalter alee end SVT discrimination algorithm have significant adventage over the older generations ICD In that they could be Implanted under local anaesthesia with less patient discomfort and have a low Incidence of Inappropriate ahooke.
