期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
DNA alkylation promoted by an electron-rich quinone methide intermediate 被引量:2
1
作者 Chengyun Huang steven e. rokita 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2016年第2期213-221,共9页
Biological application of conjugates derived from oligonucleotides and quinone methides have pre- viously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic ac... Biological application of conjugates derived from oligonucleotides and quinone methides have pre- viously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic acids. To enhance the rates of these processes, a new quinone methide precursor with an electron donating substituent has been prepared. Additionally, this substi- tuent has been placed para to the nascent exo-methylene group of the quinone methide for maximum effect. A conjugate made from this precursor and a 5'-aminohex- yloligonucleotide accelerates formation of its reversible self-adduct and alkylation of its complementary DNA as predicted from prior model studies. 展开更多
关键词 quione methide DNA alkylation reversible covalent reaction BIOCONJUGATION target-directed modification of nucleic acids
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部