In this study, we investigated possible relations between left ventricular(LV) concentric remodeling and plasma levels of high-sensitivity C-reactive protein(hs-CRP) and serum amyloid-A(SAA) in subjects who had essent...In this study, we investigated possible relations between left ventricular(LV) concentric remodeling and plasma levels of high-sensitivity C-reactive protein(hs-CRP) and serum amyloid-A(SAA) in subjects who had essential hypertension; 65 consecutive subjects who had hypertension, did not have diabetes, and had normal LV mass were categorized as those whose LV relative wall thickness was< 0.44(n=41) and those whose relative wall thickness was ≥0.44. Venous blood samples were collected for determination of metabolic profile and plasma levels of hs-CRP and SAA. Subjects whose relative LV wall thickness was ≥0.44 compared with those whose relative LV wall thickness was< 0.44 had significantly increased systolic blood pressure by 4.5 mm Hg(p=0.015) and higher levels of plasma hs-CRP(1.80 vs 1.39mg/L, p=0.001) and SAA(10.22 vs 4.86 mg/dl, p=0.000), although the 2 groups did not differ with regard to age, gender, waist-to-hip ratio, and diastolic blood pressure(p=NS for all). In the entire study population, log hs-CRP and SAA exhibited positive relations with systolic blood pressure(r=0.21 and r=0.29, respectively; p< 0.05 for the 2 markers) and relative wall thickness(r=0.26 and r=0.81, respectively; p< 0.05 for the 2 markers). Multiple linear regression analysis showed that age, gender, and diastolic blood pressure were significantly associated with LV mass index(p< 0.05), whereas gender, body mass index, log hs-CRP, and SAA were significantly associated with relative wall thickness (p< 0.003). By analysis of covariance, log hs-CRP and SAA were significantly different between subjects whose relative LV wall thickness was ≥0.44 and those whose relative LV wall thickness was< 0.44 after the adjustment for age, gender, body mass index, and systolic/diastolic blood pressure(p< 0.005 for the 2 markers). In conclusion, alterations in LV geometry are associated with increased serum CRP and SAA levels in patients who are newly diagnosed with essential hypertension.展开更多
文摘In this study, we investigated possible relations between left ventricular(LV) concentric remodeling and plasma levels of high-sensitivity C-reactive protein(hs-CRP) and serum amyloid-A(SAA) in subjects who had essential hypertension; 65 consecutive subjects who had hypertension, did not have diabetes, and had normal LV mass were categorized as those whose LV relative wall thickness was< 0.44(n=41) and those whose relative wall thickness was ≥0.44. Venous blood samples were collected for determination of metabolic profile and plasma levels of hs-CRP and SAA. Subjects whose relative LV wall thickness was ≥0.44 compared with those whose relative LV wall thickness was< 0.44 had significantly increased systolic blood pressure by 4.5 mm Hg(p=0.015) and higher levels of plasma hs-CRP(1.80 vs 1.39mg/L, p=0.001) and SAA(10.22 vs 4.86 mg/dl, p=0.000), although the 2 groups did not differ with regard to age, gender, waist-to-hip ratio, and diastolic blood pressure(p=NS for all). In the entire study population, log hs-CRP and SAA exhibited positive relations with systolic blood pressure(r=0.21 and r=0.29, respectively; p< 0.05 for the 2 markers) and relative wall thickness(r=0.26 and r=0.81, respectively; p< 0.05 for the 2 markers). Multiple linear regression analysis showed that age, gender, and diastolic blood pressure were significantly associated with LV mass index(p< 0.05), whereas gender, body mass index, log hs-CRP, and SAA were significantly associated with relative wall thickness (p< 0.003). By analysis of covariance, log hs-CRP and SAA were significantly different between subjects whose relative LV wall thickness was ≥0.44 and those whose relative LV wall thickness was< 0.44 after the adjustment for age, gender, body mass index, and systolic/diastolic blood pressure(p< 0.005 for the 2 markers). In conclusion, alterations in LV geometry are associated with increased serum CRP and SAA levels in patients who are newly diagnosed with essential hypertension.
