Dear Editor,Lung cancer is the most common cause of cancer-related mortality worldwide,with non-small cell lung cancer(NSCLC)accounting for the largest number of cases.1 Ionizing radiation(IR)is widely used as an indi...Dear Editor,Lung cancer is the most common cause of cancer-related mortality worldwide,with non-small cell lung cancer(NSCLC)accounting for the largest number of cases.1 Ionizing radiation(IR)is widely used as an indispensable tool for treating lung cancer patients;however,the acquisition of resistance following radiation is the major obstacle for reducing the efficacy of radiotherapy.展开更多
Dear Editor,Breast cancer is a leading type of cancer in women,the treatment of basal type,including triple negative breast cancer(TNBC),remains challenging due to its aggressive behaviors and lack of targeted therape...Dear Editor,Breast cancer is a leading type of cancer in women,the treatment of basal type,including triple negative breast cancer(TNBC),remains challenging due to its aggressive behaviors and lack of targeted therapeutic options1.F-box proteins(FBPs)can serve as either oncogenes or tumor suppressors depending on their substrates,and various studies have been conducted on their involvement in different types of cancer and play significant roles in cancer development and progression2.However,the related mechanisms and targets of F-box protein 15(FBX015)are still remain unclear in human breast cancers.展开更多
基金This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation(NRF)grant of the Korea Institute of Radiological and Medical Sciences(KIRAMS)funded by the Korean government(MSIT,2019M3E5D1A01069361,2019R1A2C2087551,and 50535-2020).
文摘Dear Editor,Lung cancer is the most common cause of cancer-related mortality worldwide,with non-small cell lung cancer(NSCLC)accounting for the largest number of cases.1 Ionizing radiation(IR)is widely used as an indispensable tool for treating lung cancer patients;however,the acquisition of resistance following radiation is the major obstacle for reducing the efficacy of radiotherapy.
基金This research was supported by the Bio&Medical Technology Development Program of the National Research Foundation(NRF)funded by the Korean government(MSIT)(No.2019M3E5D1A01069361)by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2019R1A2C2087551)。
文摘Dear Editor,Breast cancer is a leading type of cancer in women,the treatment of basal type,including triple negative breast cancer(TNBC),remains challenging due to its aggressive behaviors and lack of targeted therapeutic options1.F-box proteins(FBPs)can serve as either oncogenes or tumor suppressors depending on their substrates,and various studies have been conducted on their involvement in different types of cancer and play significant roles in cancer development and progression2.However,the related mechanisms and targets of F-box protein 15(FBX015)are still remain unclear in human breast cancers.
