All oral nucleoside analogues against hepatitis B virus,with an exception of telbivudine,have been reported causing lactic acidosis(LA).Here we report the first case of chronic hepatitis B developing severe refractory...All oral nucleoside analogues against hepatitis B virus,with an exception of telbivudine,have been reported causing lactic acidosis(LA).Here we report the first case of chronic hepatitis B developing severe refractory LA during telbivudine monotherapy.A 36-year-old man of Chinese origin received telbivudine antiviral treatment for chronic hepatitis B.After 11 mo of therapy,he developed anorexia,nausea,and vomiting with mild muscle weakness.The patient was found with elevated serum creatine phosphokinase up to 3683 U/L(upper limit of normal 170 U/L)and marked LA.LA did not resolve immediately following discontinuation of telbivudine.His condition began to improve after hemodialysis treatment for 16 times and usage of glucocorticosteroid.The patient fully recovered after 16 wk of treatment.This is the first documented case with severe LA caused by telbivudine monotherapy.Besides serum creatine phosphokinase,blood lactate level should also be closely monitored in patients receiving telbivudine.展开更多
To the Editor： Neurolymphomatosis （NL） is a clinical disorder that presents with peripheral neuropathy due to lymphomatous infiltration of the nerves. NL is generally associated with B-cell lymphomas, and T-cell ly...To the Editor： Neurolymphomatosis （NL） is a clinical disorder that presents with peripheral neuropathy due to lymphomatous infiltration of the nerves. NL is generally associated with B-cell lymphomas, and T-cell lymphoma is extremely rare.展开更多
To the Editor：Mutations in the mitochondrial alanyl-tRNA synthetase 2 gene （AARS2） have been recently found to lead to chronic progressive leukodystrophy or infantile cardiomyopathy.Up to date,there have been 15 pa...To the Editor：Mutations in the mitochondrial alanyl-tRNA synthetase 2 gene （AARS2） have been recently found to lead to chronic progressive leukodystrophy or infantile cardiomyopathy.Up to date,there have been 15 patients reported with chronic progressive leukodystrophy.Notably,all the female patients （9/15） present with ovarian failure,described as ＆quot;ovarioleukodystrophy.＆quot;[1-4] Herein,we report a female patient with progressive adult-onset leukodystrophy without ovarian failure due to compound heterozygous mutations in AARS2.展开更多
To the Editor:A 66-year-old female complained of muscle weakness,numbness,and pain in her left shoulder and arm for 16 months,after which muscle atrophy and forearm swelling gradually developed.Before admission,she ha...To the Editor:A 66-year-old female complained of muscle weakness,numbness,and pain in her left shoulder and arm for 16 months,after which muscle atrophy and forearm swelling gradually developed.Before admission,she had been diagnosed with brachial plexus neuritis and received intravenous methylprednisolone with 500 mg for 3 days,followed by a tapering of oral prednisolone.However,she did not benefit much from the treatment.Her personal medical history and family history were not remarkable.The previous chest computed tomography(CT)scan and magnetic resonance imaging(MRI)scans of her brain,cervical spinal cord,and brachial plexus[Figure 1A]were not remarkable.展开更多
基金Supported by National Natural Science Foundation of ChinaNo.81071354 and 81271833+4 种基金National "973’ ’ProjectNo.2012CB519001National Science and Technology Major Project of ChinaNo.2012ZX10002007-001-002No.2013ZX10002001
文摘All oral nucleoside analogues against hepatitis B virus,with an exception of telbivudine,have been reported causing lactic acidosis(LA).Here we report the first case of chronic hepatitis B developing severe refractory LA during telbivudine monotherapy.A 36-year-old man of Chinese origin received telbivudine antiviral treatment for chronic hepatitis B.After 11 mo of therapy,he developed anorexia,nausea,and vomiting with mild muscle weakness.The patient was found with elevated serum creatine phosphokinase up to 3683 U/L(upper limit of normal 170 U/L)and marked LA.LA did not resolve immediately following discontinuation of telbivudine.His condition began to improve after hemodialysis treatment for 16 times and usage of glucocorticosteroid.The patient fully recovered after 16 wk of treatment.This is the first documented case with severe LA caused by telbivudine monotherapy.Besides serum creatine phosphokinase,blood lactate level should also be closely monitored in patients receiving telbivudine.
文摘To the Editor： Neurolymphomatosis （NL） is a clinical disorder that presents with peripheral neuropathy due to lymphomatous infiltration of the nerves. NL is generally associated with B-cell lymphomas, and T-cell lymphoma is extremely rare.
文摘To the Editor：Mutations in the mitochondrial alanyl-tRNA synthetase 2 gene （AARS2） have been recently found to lead to chronic progressive leukodystrophy or infantile cardiomyopathy.Up to date,there have been 15 patients reported with chronic progressive leukodystrophy.Notably,all the female patients （9/15） present with ovarian failure,described as ＆quot;ovarioleukodystrophy.＆quot;[1-4] Herein,we report a female patient with progressive adult-onset leukodystrophy without ovarian failure due to compound heterozygous mutations in AARS2.
文摘To the Editor:A 66-year-old female complained of muscle weakness,numbness,and pain in her left shoulder and arm for 16 months,after which muscle atrophy and forearm swelling gradually developed.Before admission,she had been diagnosed with brachial plexus neuritis and received intravenous methylprednisolone with 500 mg for 3 days,followed by a tapering of oral prednisolone.However,she did not benefit much from the treatment.Her personal medical history and family history were not remarkable.The previous chest computed tomography(CT)scan and magnetic resonance imaging(MRI)scans of her brain,cervical spinal cord,and brachial plexus[Figure 1A]were not remarkable.
