Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti- microbial and anticancer potential of kosinostatin on mammary carcinoma cell line （MCF-7）. The anticancer and antipr...Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti- microbial and anticancer potential of kosinostatin on mammary carcinoma cell line （MCF-7）. The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase （LDH） and glutathione （GSH）. The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.展开更多
文摘Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti- microbial and anticancer potential of kosinostatin on mammary carcinoma cell line （MCF-7）. The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase （LDH） and glutathione （GSH）. The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.
