Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats

Aim： To investigate effects of quercetin on weight and histology of testis and accessory sex organs and on sperm quality in adult male rats. Methods： Male Sprague-Dawley rats were injected s.c. with quercetin at the dose of 0, 30, 90, or 270 mg/kg body weight/day （hereafter abbreviated Q0, Q30, Q90 and Q270, respectively）, and each dose was administered for treatment durations of 3, 7 and 14 days. Results： From our study, it was found that the effects of quercetin on reproductive organs and sperm quality depended on the dose and duration of treatment. After Q270 treatment for 14 days, the weights of testes, epididymis and vas deferens were significantly increased, whereas the weights of seminal vesicle and prostate gland were significantly decreased, compared with those of Q0. The histological alteration of those organs was observed after Q270 treatment for 7 days as well as 14 days. The sperm motility, viability and concentration were significantly increased after Q90 and Q270 injections after both of 7 and 14 days. Changes in sperm quality were earlier and greater than those in sex organ histology and weight, respectively. Conclusion： Overall results indicate that quercetin might indirectly affect sperm quality through the stimulation of the sex organs, both at the cellular and organ levels, depending on the dose and the duration of treatment. Therefore, the use of quercetin as an alternative drug for treatment of male infertility should be considered. （Asian J Androl 2008 Mar. 10： 249-258）

Medical applications of phytoestrogens from the Thai herb Pueraria mirifica

Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand.It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years.Indeed,it has been claimed that P.mirifica contains active phytoestrogens(plant substances with estrogen-like activity).Using high performance liquid chromatography,at least 17 phytoestrogens,mainly isoflavones,have been isolated.Thus,fairly considerable scientific researches,both in vitro in cell lines and in vivo in various species of animals including humans,have been conducted to date to address its estrogenic activity on the reproductive organs,bones,cardiovascular diseases and other climacteric related symptoms.The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed.In general,P.mirifica could be applicable for preventing,or as a therapeutic for,the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men.However,the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.