Multiple system atrophy(MSA)is a fatal progressive neurodegenerative disease.Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and moni...Multiple system atrophy(MSA)is a fatal progressive neurodegenerative disease.Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies.In recent years,significant research efforts have been made in exploring multidimensional biomarkers for MSA.However,currently few biomarkers are available in clinic.In this review,we systematically summarize the latest advances in multidimensional biomarkers for MSA,including biomarkers in fluids,tissues and gut microbiota as well as imaging biomarkers.Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed.展开更多
基金funded by the National Key R&D Program of China(2021YFA0805200 to H Jiang)the National Natural Science Foundation of China(81974176 and 82171254 to H Jiang)+6 种基金the Innovation Research Group Project of Natural Science Foundation of Hunan Province(2020JJ1008 to H Jiang)the Scientific Research Foundation of Health Commission of Hunan Province(B2019183 to H Jiang)the Key Research and Development Program of Hunan Province(2020SK2064 to H Jiang)the Innovative Research and Development Program of Development and Reform Commission of Hunan Province to H Jiang,the Natural Science Foundation of Hunan Province(2022JJ20094 and 2021JJ40974 to Z Chen)the Central South University Research Programme of Advanced Interdisciplinary Study(2023QYJC010 to H Jiang)the Project Program of National Clinical Research Center for Geriatric Disorders,Xiangya Hospital(2020LNJJ12 to H Jiang)the Science and Technology Innovation Program of Hunan Province(2022RC1027 to Z Chen).
文摘Multiple system atrophy(MSA)is a fatal progressive neurodegenerative disease.Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies.In recent years,significant research efforts have been made in exploring multidimensional biomarkers for MSA.However,currently few biomarkers are available in clinic.In this review,we systematically summarize the latest advances in multidimensional biomarkers for MSA,including biomarkers in fluids,tissues and gut microbiota as well as imaging biomarkers.Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed.
