Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia.Methods: The study was conducted on 55 newly diagnosed hype...Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia.Methods: The study was conducted on 55 newly diagnosed hyperlipidemic patients and 57 healthy controls.Serum paraoxonase activity and protein thiols were estimated by spectrophotometeric method and lipid profile by enzymatic kinetic assay method.Results: Serum paraoxonase activity,protein thiols and high density lipoprotein levels were low and total cholesterol,triglycerides and low density lipoprotein levels were high in patients with hyperlipidemia compared to healthy controls(P<0.01).Serum paraoxonase activity correlated positively with protein thiols and high density lipoprotein(P<0.01).Conclusion: Decreased paraoxonase activity and protein thiols were found in patients with hyperlipidemia.This may indicate the susceptibility of this population to accelerated atherogenesis and protein oxidation.展开更多
Objective:To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods: The ...Objective:To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods: The study group consisted of 26 newly diagnosed hyperlipidemic patients not associated with any other systemic diseases and 26 age and sex matched healthy controls.Fasting lipid profile was done by enzymatic method using automated analyzer.Serum copper and protein thiols were measured spectrophotometrically.Results: Serum copper and protein-SH levels were significantly decreased in cases(P<0.01,P<0.01) compared to controls.Serum copper correlated positively with protein thiols(r=0.800,P<0.01) and negatively with LDL cholesterol(r=-0.351 P<0.05).Conclusion: Serum copper and protein thiols were decreased in hyperlipidemia and they correlated positively indicating protective role of copper in preventing homocysteinylation of protein and hence in preventing atherosclerosis.展开更多
文摘Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia.Methods: The study was conducted on 55 newly diagnosed hyperlipidemic patients and 57 healthy controls.Serum paraoxonase activity and protein thiols were estimated by spectrophotometeric method and lipid profile by enzymatic kinetic assay method.Results: Serum paraoxonase activity,protein thiols and high density lipoprotein levels were low and total cholesterol,triglycerides and low density lipoprotein levels were high in patients with hyperlipidemia compared to healthy controls(P<0.01).Serum paraoxonase activity correlated positively with protein thiols and high density lipoprotein(P<0.01).Conclusion: Decreased paraoxonase activity and protein thiols were found in patients with hyperlipidemia.This may indicate the susceptibility of this population to accelerated atherogenesis and protein oxidation.
文摘Objective:To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods: The study group consisted of 26 newly diagnosed hyperlipidemic patients not associated with any other systemic diseases and 26 age and sex matched healthy controls.Fasting lipid profile was done by enzymatic method using automated analyzer.Serum copper and protein thiols were measured spectrophotometrically.Results: Serum copper and protein-SH levels were significantly decreased in cases(P<0.01,P<0.01) compared to controls.Serum copper correlated positively with protein thiols(r=0.800,P<0.01) and negatively with LDL cholesterol(r=-0.351 P<0.05).Conclusion: Serum copper and protein thiols were decreased in hyperlipidemia and they correlated positively indicating protective role of copper in preventing homocysteinylation of protein and hence in preventing atherosclerosis.
