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Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress 被引量:2
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作者 M.Subbulakshmi sugapriya dhanasekaran +3 位作者 S.Abirami M.Kannan R.Palaniappan Divya Venugopal 《Food Science and Human Wellness》 SCIE 2021年第4期452-459,共8页
Mushrooms are good sources of phytochemicals that have antioxidant and anti-proliferative effects.This study identifi ed a unique isoform of 18S rRNA gene(864 bp)from a novel wild mushroom(SMK-1)(GenBank accession num... Mushrooms are good sources of phytochemicals that have antioxidant and anti-proliferative effects.This study identifi ed a unique isoform of 18S rRNA gene(864 bp)from a novel wild mushroom(SMK-1)(GenBank accession number:SUB3267363).Thin layer chromatographic(TLC)profiling of the methanolic extract of the dried mushroom fruiting bodies of SMK-1 revealed the presence of phenolic and fl avonoid fractions with retention factor(Rf)values of 0.955 and 0.927 respectively.The GC/MS chromatograms of the SMK-1 methanolic extract identifi ed the main bioactive compound was phenol,5-methyl-2-(1-methylethyl)(74.00%)(thymol).The radical scavenging activity for the fl avonoid fraction was greater than the phenolic fractions(Rf–phenolics fractions>Rf–fl avonoid fractions)with the antioxidant activity more than that of standard ascorbic acid.Also,the phenolic and flavonoid fractions of SMK-1 expressed cytotoxic effects in HeLa cells with IC50 values ranging from 5μg/mL to 80μg/mL in a dose-dependent manner.This present research highlights the presence of high thymol concentration in a novel wild mushroom that has antioxidant and anti-poliferative potential with therapeutic benefi ts.The application of thymol natural products from novel mushroom SMK-1 as nutrition supplements could inhibit oxidative stress triggered by numerous pathologies that may pave the way to develop a new therapeutic natural drug. 展开更多
关键词 Antioxidant ANTI-PROLIFERATION Dietary mushrooms HeLa cells Novel Mushrooms THYMOL
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Delineating the role of phytocompounds against anti-bacterial drug resistance–An update
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作者 REKHA GAHTORI MOSLEH MOHAMMAD ABOMUGHAID +7 位作者 NIDHI NEGI SARAVANAN KRISHNAN sugapriya dhanasekaran SOUMYA PANDIT KANU PRIYA DILLIP KUMAR BISHI RAM PRASAD PIYUSH KUMAR GUPTA 《BIOCELL》 SCIE 2021年第6期1465-1477,共13页
Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization.This kind of problem is not limited to India only,but it is a global concern.Nowadays... Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization.This kind of problem is not limited to India only,but it is a global concern.Nowadays,many treatments and medicines for bacterial diseases have been developed.However,they possess some drawbacks.Therefore,the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary.Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria.In recent years,researchers have also focused on new drug discovery from plant-based research.They have looked on various phytocompounds as antibacterial agents.In the current review,we report various classes of secondary metabolites such as phenolic compounds,flavonoids,alkaloids,saponins,terpenes,quinones,and some essential oils that have been used as an antibacterial agent.In addition,we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis. 展开更多
关键词 DRUG-RESISTANCE Phytocompounds ANTIBACTERIAL MECHANISMS Medicinal plants Natural products
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