Purpose: To investigate potential pathological differences in major brain metabolites in burning mouth syndrome (BMS). Materials and Methods: We prospectively evaluated eight patients and six healthy controls with sin...Purpose: To investigate potential pathological differences in major brain metabolites in burning mouth syndrome (BMS). Materials and Methods: We prospectively evaluated eight patients and six healthy controls with single voxel magnetic resonance (MR) spectroscopy throughout 2017 using 3-Tesla MR unit. Metabolite levels measured from the left posterior paracingulate white matter. Raw images were processed with Tarquin version 4.3.10 and area under curve values were automatically calculated for GABA (γ-Aminobutyric acid), Ins (myo-inositole), tNAA (N-Acetylaspartate), tCho (total choline), tCr (total creatine) and GLx (glutamine + Glutamat). Major metabolite levels and all metabolites ratio to tCr calculated and compared between two groups using Mann-Whitney U test. Results: GABA/tCR value of the patients (0.589 ± 0.194, median = 0.515) was significantly higher than control group (0.230 ± 0.067, median = 0.220) (P = 0.002). tNAA/tCR value of the patients (1.106 ± 0.218, median: 1.205), was significantly lower than the control group (1.538 ± 0.401, median: 1.705) (P = 0.028). No significant difference was observed between two groups in terms of all other metabolites (P > 0.05). Conclusion: We demonstrated increased GABA and decreased NAA in the left posterior paracingulate region in BMS patients. We suggest that these metabolite alterations in central nervous system might play a key role in the etiology of the disease by inhibiting the suppression of burning sensation.展开更多
Novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a pathogen that has caused a rapidly spreading pandemic all over the world.The primary mean of transmission is ...Novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a pathogen that has caused a rapidly spreading pandemic all over the world.The primary mean of transmission is inhalation with a predilection for respiratory system involvement,especially in the distal airways.The disease that arises from this novel coronavirus is named coronavirus disease 2019(COVID-19).COVID-19 may have a rapid and devastating course in some cases leading to severe complications and death.Radiological imaging methods have an invaluable role in diagnosis,follow-up,and treatment.In this review,radiological imaging findings of COVID-19 have been systematically reviewed based on the published literature so far.Radiologic reporting templates are also emphasized from a different point of view,considering specific distinctive patterns of involvement.展开更多
文摘Purpose: To investigate potential pathological differences in major brain metabolites in burning mouth syndrome (BMS). Materials and Methods: We prospectively evaluated eight patients and six healthy controls with single voxel magnetic resonance (MR) spectroscopy throughout 2017 using 3-Tesla MR unit. Metabolite levels measured from the left posterior paracingulate white matter. Raw images were processed with Tarquin version 4.3.10 and area under curve values were automatically calculated for GABA (γ-Aminobutyric acid), Ins (myo-inositole), tNAA (N-Acetylaspartate), tCho (total choline), tCr (total creatine) and GLx (glutamine + Glutamat). Major metabolite levels and all metabolites ratio to tCr calculated and compared between two groups using Mann-Whitney U test. Results: GABA/tCR value of the patients (0.589 ± 0.194, median = 0.515) was significantly higher than control group (0.230 ± 0.067, median = 0.220) (P = 0.002). tNAA/tCR value of the patients (1.106 ± 0.218, median: 1.205), was significantly lower than the control group (1.538 ± 0.401, median: 1.705) (P = 0.028). No significant difference was observed between two groups in terms of all other metabolites (P > 0.05). Conclusion: We demonstrated increased GABA and decreased NAA in the left posterior paracingulate region in BMS patients. We suggest that these metabolite alterations in central nervous system might play a key role in the etiology of the disease by inhibiting the suppression of burning sensation.
文摘Novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a pathogen that has caused a rapidly spreading pandemic all over the world.The primary mean of transmission is inhalation with a predilection for respiratory system involvement,especially in the distal airways.The disease that arises from this novel coronavirus is named coronavirus disease 2019(COVID-19).COVID-19 may have a rapid and devastating course in some cases leading to severe complications and death.Radiological imaging methods have an invaluable role in diagnosis,follow-up,and treatment.In this review,radiological imaging findings of COVID-19 have been systematically reviewed based on the published literature so far.Radiologic reporting templates are also emphasized from a different point of view,considering specific distinctive patterns of involvement.
