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Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population
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作者 suhani h. almal Anuroopa Gupta harish Padh 《Journal of Health Science》 2015年第6期276-281,共6页
HIV-1 infection requires the expression of CD4+ molecules in colligation with C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4) as the major coreceptors. The role of SNP in 3' untr... HIV-1 infection requires the expression of CD4+ molecules in colligation with C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4) as the major coreceptors. The role of SNP in 3' untranslated region ofSDF-1 (SDF1-3 'A) and low copy number (CN) of the CCL3L1 gene is reported to confer increased resistance to HIV-1 infection. The aim of the present study was to analyze the combinatorial effect of both the variations in protection towards HIV-1 infection in Indian population. The combinatorial effect of genetic variation in terms of SNP in SDF-1 gene and CCL3L1 CN was investigated in 105 healthy individuals and 78 HIV-I patients. Genotyping of SDF-1 was performed by RFLP-PCR and CCL3L1 by real-time PCR using TaqMan chemistry. The genotype frequency distribution of SDF-1 was found to be (SDF-1/SDF-I: 65.4%, SDF-1/SDF1-3'A: 29.5% and SDFI-3'A/SDF1-3'A- 5.1%) in HIV patients as compared to (SDF-1/SDF-I: 64.8%, SDF-1/SDF1-3'A: 30.5% and SDF1-3 'A/SDF1-3 'A: 4.7%) in healthy individuals, whereas a range of 1 to 6 copies per diploid genome was observed for CCL3L1 gene. 展开更多
关键词 CCL3L1 CORECEPTOR gene copy number HIV-1 SDF-1 SNP.
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