Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has affected millions of people across the world engendering an unprecedented pandemic.Coronavirus disease(COVID)-19 can present asymptomatic or in the form o...Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has affected millions of people across the world engendering an unprecedented pandemic.Coronavirus disease(COVID)-19 can present asymptomatic or in the form of the acute respiratory syndrome,viral pneumonia,or sepsis.Due to the novelty of the disease,the endocrine manifestations are not fully understood.It becomes indispensable to address the underlying endocrine disruptions contributing to the severe form of illness and thereby increasing the mortality.We discuss here the SARS-CoV-2 virus and endocrine reverberations based on the research with structurally similar SARS-COV-1.SARS-CoV-2 enters the body via its attachment to the angiotensin-converting enzyme 2(ACE2)receptors.Apart from lungs,ACE2 expression on various organs can lead to endocrine perturbations.In COVID-19 infection,pre-existing endocrine disorders warrant cautious management and may require replacement therapy.COVID-19 and its repercussions on hormones are discussed extensively in this review.展开更多
Typical cleft hand is a rare disorder usually inherited in an autosomal-dominant manner.We report a case of bilateral typical cleft hand in a 6-year-old male.There was no positive family history of such presentation,a...Typical cleft hand is a rare disorder usually inherited in an autosomal-dominant manner.We report a case of bilateral typical cleft hand in a 6-year-old male.There was no positive family history of such presentation,and no systemic manifestations were associated with this entity.Preanesthetic evaluation revealed no systemic or airway challenges and parents were counseled for routine surgical and anesthetic risks.The hands underwent successful surgical reconstruction with no peri-operative complications.To the best of our knowledge,this is thefirst report of an operated case of an isolated,bilateral,and sporadic typical split hand malformation.展开更多
文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has affected millions of people across the world engendering an unprecedented pandemic.Coronavirus disease(COVID)-19 can present asymptomatic or in the form of the acute respiratory syndrome,viral pneumonia,or sepsis.Due to the novelty of the disease,the endocrine manifestations are not fully understood.It becomes indispensable to address the underlying endocrine disruptions contributing to the severe form of illness and thereby increasing the mortality.We discuss here the SARS-CoV-2 virus and endocrine reverberations based on the research with structurally similar SARS-COV-1.SARS-CoV-2 enters the body via its attachment to the angiotensin-converting enzyme 2(ACE2)receptors.Apart from lungs,ACE2 expression on various organs can lead to endocrine perturbations.In COVID-19 infection,pre-existing endocrine disorders warrant cautious management and may require replacement therapy.COVID-19 and its repercussions on hormones are discussed extensively in this review.
文摘Typical cleft hand is a rare disorder usually inherited in an autosomal-dominant manner.We report a case of bilateral typical cleft hand in a 6-year-old male.There was no positive family history of such presentation,and no systemic manifestations were associated with this entity.Preanesthetic evaluation revealed no systemic or airway challenges and parents were counseled for routine surgical and anesthetic risks.The hands underwent successful surgical reconstruction with no peri-operative complications.To the best of our knowledge,this is thefirst report of an operated case of an isolated,bilateral,and sporadic typical split hand malformation.
