Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have brui...Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have bruising in the vicinity of the umbilicus (Cullen’s sign). She had pronounced ovarian enlargement on ultrasonography and it was hypothesised that this profound phenotype might reflect an abnormal FSH receptor.However sequencing of the FSH receptor was normal.The ovarian enlargement resolved with thyroxine replacement.Physicians and surgeons should consider longstanding hypothyroidismin patients presenting with Cullen’s sign.展开更多
文摘Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have bruising in the vicinity of the umbilicus (Cullen’s sign). She had pronounced ovarian enlargement on ultrasonography and it was hypothesised that this profound phenotype might reflect an abnormal FSH receptor.However sequencing of the FSH receptor was normal.The ovarian enlargement resolved with thyroxine replacement.Physicians and surgeons should consider longstanding hypothyroidismin patients presenting with Cullen’s sign.
