Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide

Intrauterine adhesion(IUA)is a common clinical endometrial disease,which can severely damage the fertility and quality of life in women.This study aims to find the differentially expressed endogenous peptides and their possible roles in IUA.Liquid chromatography-mass spectrometry was used to identify the peptidomic profiling of IUA tissues,and the differentially expressed peptides were screened out.Using real-time quantitative PCR,Western blotting,and immunocytochemistry staining,the function of six endogenous peptides was verified in vitro.It was found that peptide 6(T6)(peptide sequence:TFGGAPGFPLGSPLSSVFPR)could inhibit the expression of TGF-β1-induced cell fibrosis in human endometrial stromal cell line and primary human endometrial stromal cell at a concentration of 50μmol/L.This study provides new targets for further clarifying the formation and prevention of IUA.

Temporal and spatial distribution characteristics of nutrients in Clarion-Clipperton Fracture Zone in the Pacific in 2017

This research investigated eight stations in Clarion-Clipperton Fracture Zone(CCFZ)in the eastern tropical Pacific in 2017 to study the spatial distribution characteristics of nutrients and chlorophyll a(Chi a)concentration,and compared nutrient concentrations and molar ratios with those of other investigations 20 years ago in the same area.The study found that dissolved inorganic nutrient(N,P and Si)concentrations were lowest in the upper layer,and increased from surface to some depths,then they decreased a little to the bottom.N was the limited nutrient factor for the growth of phytoplankton community.Although nutrient concentrations and molar ratios have no obvious changes in 2017 comparing those in 1998-2003,supplemented from the equatorial Pacific,nutrient concentrations in the study area were higher than those in seamounts in the North Pacific and Station ALOHA.Furthermore,this study used Generalized Additive Models(GAMs)to infer the underlying bottom-up factors controlling phytoplankton abundance(Chi a concentration),showing that depth,salinity and PO^-P concentration were major factors controlling the growth of phytoplankton community.Furthermore,this study can provide basic data and theoretical support for the development of polymetallic nodule area and its long-term impact assessment on the environment.

Deciphering a Million-Plus RSA Integer with Ultralow Local Field Coefficient h and Coupling Coefficient J of the Ising Model by D-Wave 2000Q

This work is the first to determine that a real quantum computer(including generalized and specialized)can decipher million-scale RSA relying solely on quantum algorithms,showing the real attack potential of D-Wave machines.The influence of different column widths on RSA factorization results is studied on the basis of a multiplication table,and the optimal column method is determined by traversal experiments.The traversal experiment of integer factorization within 10000 shows that the local field and coupling coefficients are 75%–93%lower than the research of Shanghai University in 2020 and more than 85%lower than that of Purdue University in 2018.Extremely low Ising model parameters are crucial to reducing the hardware requirements,prompting factoring 1245407 on the D-Wave 2000Q real machine.D-Wave advantage already has more than 5000 qubits and will be expanded to 7000 qubits during 2023–2024,with remarkable improvements in decoherence and topology.This machine is expected to promote the solution of large-scale combinatorial optimization problems.One of the contributions of this paper is the discussion of the long-term impact of D-Wave on the development of post-quantum cryptography standards.

Efficacy of intrauterine balloon stent or oral estrogen on prevention of adhesion after transcervical resection of septum in septate uterus:Study protocol for a randomized controlled multicenter study in China

To the Editor:The septate uterus is the most common uterine anomaly and is associated with an increased risk of adverse reproductive outcomes.Transcervical resection of septum(TCRS)is widely performed in patients with adverse reproductive outcomes.The incidence of de novo intrauterine adhesions(IUAs)after TCRS is approximately 5%to 25%.[1]Various anti-adhesion methods are widely used in the clinical management of patients with septate uteri,including intrauterine devices,Foley balloons,estrogen,antibiotics,and hyaluronic acid gel.However,insufficient evidence supports or opposes any of these methods(Level C),[2]lacking high-grade evidence.

Research on recognition algorithm for gesture page turning based on wireless sensing

When a human body moves within the coverage range of Wi-Fi signals,the reflected Wi-Fi signals by the various parts of the human body change the propagation path,so analysis of the channel state data can achieve the perception of the human motion.By extracting the Channel State Information(CSI)related to human motion from the Wi-Fi signals and analyzing it with the introduced machine learning classification algorithm,the human motion in the spatial environment can be perceived.On the basis of this theory,this paper proposed an algorithm of human behavior recognition based on CSI wireless sensing to realize deviceless and over-the-air slide turning.This algorithm collects the environmental information containing upward or downward wave in a conference room scene,uses the local outlier factor detection algorithm to segment the actions,and then the time domain features are extracted to train Support Vector Machine(SVM)and eXtreme Gradient Boosting(XGBoost)classification modules.The experimental results show that the average accuracy of the XGBoost module sensing slide flipping can reach 94%,and the SVM module can reach 89%,so the module could be extended to the field of smart classroom and significantly improve speech efficiency.

Lake records and LGM climate in China

Chinese lake status database has provided systematic geological records of much higher lake level and fresher water than today at the LGM from western China. This wet condition was significant contrast with very dry conditions in eastern China. Together with lake studies from Eurasian continents, there was a wet-condition belt from the Mediterranean and the Middle East, Central Asia to western China. Palaeoclimate simulations confirmed that the wet conditions in western China were produced by decrease of the evaporation and increase of precipitation by positive anomaly of annual P-E of 70-95 mm/a between the LGM and today. The westerlies enhanced in the strength and shifted southwards-eastwards in the position, and the low thermal conditions in the Eurasian continent creating temperature 4-16℃ lower than today and relatively low evaporation, were the major two important climate conditions to yield cold-wet climates in western China.

Environmental evolution and southwest monsoon changes in mid-Holocene recorded by lake sediments in Erhai Lake

IN recent years, much progress has been made in the research of the temporal and spatial changes of East Asian monsoon. To research the environmental evolution and monsoon variations in Holocene in the region of Southwest China, a 310-cm continuous lake sediments core in Erhai Lake, Yunnan Province was sampled with Livingston sampler on July 6, 1996. The lake sediments were separated at 2-cm intervals and the core samples were analyzed with chronology, stable isotope ratios of organic carbon and diatoms determination. Three 14C ages are （4 473±40）a B.P. （98—102 cm）, （5 825±85） a B. P. （144—148 cm） and （7 754±45） a B.P. （198—202 cm）. By 137Cs dating, the sedimentation rate is about 0.3 mm/a and this result is close to the 14C dating results. The average sedimentation rates

Defect engineering for high-selection-performance of NO reduction to NH3 over CeO_(2)(111)surface:A DFT study

To reduce the greenhouse effect caused by the surgery of nitrogen-oxides concentration in the atmosphere and develop a future energy carrier of renewables,it is very critical to develop more efficient,controllable,and highly sensitive catalytic materials.In our work,we proposed that nitric oxide(NO),as a supplement to N_(2) for the synthesis of ammonia,which is equipped with a lower barrier.And the study highlighted the potential of CeO_(2)(111)nanosheets with La doping and oxygen vacancy(OV)as a high-performance,controllable material for NO capture at the site of Vo site,and separation the process of hydrogenation.We also reported that the E_(ads) of-1.12 eV with horizontal adsorption and the Bader charge of N increasing of 0.53|e|and O increasing of 0.17|e|at the most active site of reduction-OV predicted.It is worth noting thatΔG of NORR(NO reduction reaction)shows good performance(thermodynamically spontaneous reaction)to synthesize ammonia and water at room temperature in the theoretical calculation.

The abundance,characteristics and diversity of microplastics in the South China Sea:Observation around three remote islands

Surrounded by emerging markets with considerable plastic consumption,the South China Sea has been a focus area of microplastic research.A survey on the floating microplastics(>0.3 mm)and microplastics ingested by fish and mollusks was conducted around three remote islands here.Compared with the results from several previous studies,a high abundance of floating microplastics(with a median of 1.9×10^(5)items/km^(2) or 0.7 items/m^(3))was observed,revealing another“hot spot”for microplastics.Polyolefin,especially polypropylene,was the main component.The diversity index and evenness index were calculated and evaluated based on the composition of microplastics.The characteristic peaks of Raman spectra concerning pigmented microplastics were provided.Transparent sheets/films were predominant in the water sample,which was quite different from a similar study in this sea area(8.9%for film),and only 16.4%of floating microplastics(>0.3 mm)were fibers/lines,implying that the main sources of floating microplastics(>0.3 mm)might be household/agricultural consumption activities.The transparent fiber/line was also dominant in organisms.It is suggested that the main sources of microplastics ingested by organisms might be both fabric fibers and fishing/aquaculture.

An asymptotically optimal public parking lot location algorithm based on intuitive reasoning

In order to solve the problems of road traffic congestion and the increasing parking time caused by the imbalance of parking lot supply and demand,this paper proposes an asymptotically optimal public parking lot location algorithm based on intuitive reasoning to optimize the parking lot location problem.Guided by the idea of intuitive reasoning,we use walking distance as indicator to measure the variability among location data and build a combinatorial optimization model aimed at guiding search decisions in the solution space of complex problems to find optimal solutions.First,Selective Attention Mechanism(SAM)is introduced to reduce the search space by adaptively focusing on the important information in the features.Then,Quantum Annealing(QA)algorithm with quantum tunneling effect is used to jump out of the local extremum in the search space with high probability and further approach the global optimal solution.Experiments on the parking lot location dataset in Luohu District,Shenzhen,show that the proposed method has improved the accuracy and running speed of the solution,and the asymptotic optimality of the algorithm and its effectiveness in solving the public parking lot location problem are verified.

Sedimentologic evidence for date of southward moving of the Yangtze River in the Jianghan Plain since the Holocene

The study of the sediment of Core M1 from Jianghan Plain suggests that the sediment source of this area changed in the Holocene, which corresponds with the south moving of the Yangtze River. Since then, the sediment source has been mainly from the Hanshui River.

Shaping the future of the application of quantum computing in intelligent transportation system

The intelligent transportation system(ITS)integrates a variety of advanced science and technology to support and monitor road traffic systems and accelerate the urbanization process of various countries.This paper analyzes the shortcomings of ITS,introduces the principle of quantum computing and the performance of universal quantum computer and special-purpose quantum computer,and shows how to use quantum advantages to improve the existing ITS.The application of quantum computer in transportation field is reviewed from three application directions:path planning,transportation operation management,and transportation facility layout.Due to the slow development of the current universal quantum computer,the D-Wave quantum machine is used as a breakthrough in the practical application.This paper makes it clear that quantum computing is a powerful tool to promote the development of ITS,emphasizes the importance and necessity of introducing quantum computing into intelligent transportation,and discusses the possible development direction in the future.