Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes...Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.展开更多
以酚醛树脂溶液为前驱体、石英针刺预制体为增强体,采用RTM(Resin transfer molding)复合浸渍成型的方法制备得到具有纳米多孔结构的酚醛气凝胶/石英纤维复合材料。调整酚醛树脂前驱体的酚醛树脂、二氧化硅含量和固化剂含量,对制备得到...以酚醛树脂溶液为前驱体、石英针刺预制体为增强体,采用RTM(Resin transfer molding)复合浸渍成型的方法制备得到具有纳米多孔结构的酚醛气凝胶/石英纤维复合材料。调整酚醛树脂前驱体的酚醛树脂、二氧化硅含量和固化剂含量,对制备得到的酚醛气凝胶/石英纤维复合材料的性能进行对比分析。研究表明:随着酚醛树脂固含量的提高,复合材料的收缩率明显提高,压缩变形量则先降低后略有增大,导热系数先减小后增大,密度逐渐增大;随着固化剂含量的增大,复合材料的收缩率明显增大,压缩变形量明显降低,密度略有提高,导热系数则呈现先减小后增大的趋势;随着二氧化硅含量的增大,复合材料的收缩率和压缩变形量变化不明显,导热系数和密度均略有提高;溶胶前驱体黏度逐渐增大,复合材料的残重率也有所提高。通过调控酚醛树脂前驱体比例,能够改变材料的收缩、力学、隔热、密度等性能,以满足不同的热防护应用需求。展开更多
基金Training Program for Young Qhuang Scholars[Chinese Medicine Education Letter(2022)No.256]Key Research and Development Program of Anhui Province(No.202204295107020001)+1 种基金Anhui Young Leaders Reserve Talent Project[No.4,Middle Development(2022)]National Natural Science Foundation of China(No.81973825,82104783)。
文摘Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.
文摘以酚醛树脂溶液为前驱体、石英针刺预制体为增强体,采用RTM(Resin transfer molding)复合浸渍成型的方法制备得到具有纳米多孔结构的酚醛气凝胶/石英纤维复合材料。调整酚醛树脂前驱体的酚醛树脂、二氧化硅含量和固化剂含量,对制备得到的酚醛气凝胶/石英纤维复合材料的性能进行对比分析。研究表明:随着酚醛树脂固含量的提高,复合材料的收缩率明显提高,压缩变形量则先降低后略有增大,导热系数先减小后增大,密度逐渐增大;随着固化剂含量的增大,复合材料的收缩率明显增大,压缩变形量明显降低,密度略有提高,导热系数则呈现先减小后增大的趋势;随着二氧化硅含量的增大,复合材料的收缩率和压缩变形量变化不明显,导热系数和密度均略有提高;溶胶前驱体黏度逐渐增大,复合材料的残重率也有所提高。通过调控酚醛树脂前驱体比例,能够改变材料的收缩、力学、隔热、密度等性能,以满足不同的热防护应用需求。
