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CT引导下经皮穿刺组织中TTF-1、NapsinA表达量与癌细胞恶性生物学的相关性 被引量:5
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作者 孙文国 孔延亮 王琦 《海南医学院学报》 CAS 2018年第7期811-814,共4页
目的:研究CT引导下经皮穿刺组织中甲状腺转录因子-1(TTF-1)、天冬氨酸蛋白酶A(NapsinA)表达量与癌细胞恶性生物学的相关性。方法:选择2015年3月-2017年12月期间铜川市人民医院CT引导下经皮穿刺获得的肺组织,经病理诊断为肺癌组织78例、... 目的:研究CT引导下经皮穿刺组织中甲状腺转录因子-1(TTF-1)、天冬氨酸蛋白酶A(NapsinA)表达量与癌细胞恶性生物学的相关性。方法:选择2015年3月-2017年12月期间铜川市人民医院CT引导下经皮穿刺获得的肺组织,经病理诊断为肺癌组织78例、良性组织40例,抽提RNA后测定TTF-1、NapsinA、癌基因及上皮间质转化(EMT)基因的表达量。结果:肺癌组织中TTF-1、Pim1、Cmyc、Nr4a1、KLF4、N-cadherin的mRNA表达量显著高于良性组织、NapsinA、Rb、LKB1、HIPK2、Ecadherin的mRNA表达量显著低于良性组织;TTF-1高表达的肺癌组织中Pim1、C-myc的mRNA表达量显著高于TTF-1低表达的肺癌组织,Rb、LKB1的mRNA表达量显著低于TTF-1低表达的肺癌组织;NapsinA高表达的肺癌组织中HIPK2、E-cadherin的mRNA表达量显著高于NapsinA低表达的肺癌组织,Nr4a1、KLF4、N-cadherin的mRNA表达量显著低于NapsinA低表达的肺癌组织。结论:CT引导下经皮穿刺组织中高表达的TTF-1和低表达的NapsinA分别能够促进癌细胞的增殖及EMT。 展开更多
关键词 肺癌 甲状腺转录因子-1 天冬氨酸蛋白酶A 细胞增殖 上皮间质转化
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Joint inversion method for interval quality factor based on amplitude and phase information 被引量:1
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作者 Cao Dan-Ping Li Yue +1 位作者 sun wen-guo Liang Kai 《Applied Geophysics》 SCIE CSCD 2019年第2期199-208,253-254,共12页
Estimating the quality factor Q accurately signifi cantly improves the seismic data resolution and reservoir characterization.The commonly used log-spectral ratio method uses least-squares fi tting to obtain Q values ... Estimating the quality factor Q accurately signifi cantly improves the seismic data resolution and reservoir characterization.The commonly used log-spectral ratio method uses least-squares fi tting to obtain Q values and involves only the amplitude information of seismic data while neglecting phase information.This paper proposes a joint interval Q inversion method based on the spectral ratio method and employs both amplitude and phase information to improve the accuracy.Based on the assumption that Q is independent of frequency,the nonlinear relation between the Q value and the two types of information is jointly used to construct an objective function,which clarifies the quantitative relation between amplitude spectrum,phase information,and Q value.The interval Q value can be inverted by calculating the minimum value of the objective function.The model test exhibits that the proposed method has higher precision and stability than the spectral ratio method;furthermore,the application to field data demonstrates that accurate Q inversion results are consistent with reservoir characteristics. 展开更多
关键词 viscoelastic medium quality factor AMPLITUDE PHASE
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