Fiber products for microwave kilns were prepared using alumina fibers with alumina contents of 72 mass%and 80 mass%,and calcined alumina powder(4-6μm)as the main raw materials,silica sol as the binder,and cationic st...Fiber products for microwave kilns were prepared using alumina fibers with alumina contents of 72 mass%and 80 mass%,and calcined alumina powder(4-6μm)as the main raw materials,silica sol as the binder,and cationic starch as the flocculant.Effects of different raw materials and their additions on the wave transparency of fiber products were researched.The results show that as the alumina fiber(72%)addition increases,the heating rate of the samples first decreases and then increases,and the corresponding wave transparency of the sample first increases and then decreases.When the alumina fibers addition is 40 mass%and the alumina powder addition is 30 mass%,the prepared microwave kiln lining material has a higher mullite content,which improves the wave transparency of the sample.The sample prepared from alumina fibers with an alumina content of 80%has a suitable glass-mullite phase ratio,performs lower overall dielectric constant and good wave transparency,and is a suitable lining material for microwave kilns.展开更多
常规SAGD开采蒸汽超覆现象严重、蒸汽腔发育不均匀、后期开发效果差,非凝析气体辅助SAGD开采即SAGP(steam and gas push)可有效改善SAGD开发效果,但SAGP开采机理、开发特征和影响因素仍未完全明确。采用室内实验和数值模拟相结合方法,揭...常规SAGD开采蒸汽超覆现象严重、蒸汽腔发育不均匀、后期开发效果差,非凝析气体辅助SAGD开采即SAGP(steam and gas push)可有效改善SAGD开发效果,但SAGP开采机理、开发特征和影响因素仍未完全明确。采用室内实验和数值模拟相结合方法,揭示SAGP开采机理,明确蒸汽腔发育、剩余油分布等开发特征,探讨非凝析气体类型、注入方式、注入时机等因素的影响规律。结果表明:非凝析气体可降低稠油黏度和储层顶部热量损失速率,从而提高稠油可流动性和蒸汽热利用效率;SAGP过程中利用二氧化碳的辅助效果优于甲烷和氮气,尽早注入非凝析气体可形成“椭圆形”蒸汽腔;非凝析气体注入速率为4000 m^(3)/d时效果最好,超过该值非凝析气体会抑制蒸汽腔发育;采用段塞式注入非凝析气体效果优于连续式注入方式,最优段塞长度为2个月。研究结果对于加拿大油砂SAGP高效开发具有重要意义。展开更多
Combretastatin A-4(CA-4)是一个天然的秋水仙碱结合位点的微管蛋白抑制剂,具有抗肿瘤活性。PI3K信号通路是细胞内重要的信号转导通路之一,也是癌细胞中常见的异常表达信号通路。微管蛋白抑制剂和信号通路激酶抑制剂均为抗肿瘤药物研发...Combretastatin A-4(CA-4)是一个天然的秋水仙碱结合位点的微管蛋白抑制剂,具有抗肿瘤活性。PI3K信号通路是细胞内重要的信号转导通路之一,也是癌细胞中常见的异常表达信号通路。微管蛋白抑制剂和信号通路激酶抑制剂均为抗肿瘤药物研发的热点。设计、筛选并合成了具有秋水仙碱和PI3K双靶点的CA-4衍生物。利用SBDD技术,采用活性基团协作的方法,对CA-4进行秋水仙碱和PI3K双靶点结构改造。结合CA-4的构效关系,保留A环及3个甲氧基,以羰基取代连接双键碳以保证顺式构型,苯并呋喃环取代B环,B环侧链引入卤素增效,依据结合活性自由能打分值筛选出9种靶点活性高的衍生物进行分子对接分析及可视化分析,并通过碘代、溴代、Rap-Stoermer偶联反应和Heck偶联反应合成目标化合物CA-4,其结构经1 H NMR、13 C NMR和MS确证。活性测试结果表明:目标化合物对乳腺癌MCF-7和MDA-MB-2312种肿瘤细胞具有抑制作用。展开更多
文摘Fiber products for microwave kilns were prepared using alumina fibers with alumina contents of 72 mass%and 80 mass%,and calcined alumina powder(4-6μm)as the main raw materials,silica sol as the binder,and cationic starch as the flocculant.Effects of different raw materials and their additions on the wave transparency of fiber products were researched.The results show that as the alumina fiber(72%)addition increases,the heating rate of the samples first decreases and then increases,and the corresponding wave transparency of the sample first increases and then decreases.When the alumina fibers addition is 40 mass%and the alumina powder addition is 30 mass%,the prepared microwave kiln lining material has a higher mullite content,which improves the wave transparency of the sample.The sample prepared from alumina fibers with an alumina content of 80%has a suitable glass-mullite phase ratio,performs lower overall dielectric constant and good wave transparency,and is a suitable lining material for microwave kilns.
文摘常规SAGD开采蒸汽超覆现象严重、蒸汽腔发育不均匀、后期开发效果差,非凝析气体辅助SAGD开采即SAGP(steam and gas push)可有效改善SAGD开发效果,但SAGP开采机理、开发特征和影响因素仍未完全明确。采用室内实验和数值模拟相结合方法,揭示SAGP开采机理,明确蒸汽腔发育、剩余油分布等开发特征,探讨非凝析气体类型、注入方式、注入时机等因素的影响规律。结果表明:非凝析气体可降低稠油黏度和储层顶部热量损失速率,从而提高稠油可流动性和蒸汽热利用效率;SAGP过程中利用二氧化碳的辅助效果优于甲烷和氮气,尽早注入非凝析气体可形成“椭圆形”蒸汽腔;非凝析气体注入速率为4000 m^(3)/d时效果最好,超过该值非凝析气体会抑制蒸汽腔发育;采用段塞式注入非凝析气体效果优于连续式注入方式,最优段塞长度为2个月。研究结果对于加拿大油砂SAGP高效开发具有重要意义。
文摘Combretastatin A-4(CA-4)是一个天然的秋水仙碱结合位点的微管蛋白抑制剂,具有抗肿瘤活性。PI3K信号通路是细胞内重要的信号转导通路之一,也是癌细胞中常见的异常表达信号通路。微管蛋白抑制剂和信号通路激酶抑制剂均为抗肿瘤药物研发的热点。设计、筛选并合成了具有秋水仙碱和PI3K双靶点的CA-4衍生物。利用SBDD技术,采用活性基团协作的方法,对CA-4进行秋水仙碱和PI3K双靶点结构改造。结合CA-4的构效关系,保留A环及3个甲氧基,以羰基取代连接双键碳以保证顺式构型,苯并呋喃环取代B环,B环侧链引入卤素增效,依据结合活性自由能打分值筛选出9种靶点活性高的衍生物进行分子对接分析及可视化分析,并通过碘代、溴代、Rap-Stoermer偶联反应和Heck偶联反应合成目标化合物CA-4,其结构经1 H NMR、13 C NMR和MS确证。活性测试结果表明:目标化合物对乳腺癌MCF-7和MDA-MB-2312种肿瘤细胞具有抑制作用。
