Hot flashes(HF)caused by low estrogen in menopause result from changes ir thermoregulatory processes in the hypothalamic preoptic area(POA).In the POA,transient receptor potential vanilloid 1(TRPV1)participate in heat...Hot flashes(HF)caused by low estrogen in menopause result from changes ir thermoregulatory processes in the hypothalamic preoptic area(POA).In the POA,transient receptor potential vanilloid 1(TRPV1)participate in heat dissipation processes.Studies suggest that TRPV1 expression may be regulated by norepinephrine(NE)-activated α2-adrenergic receptors(α2-ADR)in dorsal root ganglia.The goal of this study is to investigate the relationship between NE regulated TRPV1 expression in POA of ovariectomized rats and the development of HF.Ninety female adult Sprague-Dawley rats were divided into three groups:SHAM,OVX and E2.In the POA,the expression of TRPV1 and α2-ADR were determined using immunohistochemistry and Western blotting after 4 weeks of estrogen treatment,and NE content was detected using high-performance liquid chromatography.展开更多
文摘Hot flashes(HF)caused by low estrogen in menopause result from changes ir thermoregulatory processes in the hypothalamic preoptic area(POA).In the POA,transient receptor potential vanilloid 1(TRPV1)participate in heat dissipation processes.Studies suggest that TRPV1 expression may be regulated by norepinephrine(NE)-activated α2-adrenergic receptors(α2-ADR)in dorsal root ganglia.The goal of this study is to investigate the relationship between NE regulated TRPV1 expression in POA of ovariectomized rats and the development of HF.Ninety female adult Sprague-Dawley rats were divided into three groups:SHAM,OVX and E2.In the POA,the expression of TRPV1 and α2-ADR were determined using immunohistochemistry and Western blotting after 4 weeks of estrogen treatment,and NE content was detected using high-performance liquid chromatography.
