Vibrating Liquefaction Experiment and Mechanism Study in Saturated Granular Media

By the vibrating liquefaction experiment of tailings and fine-ores of iron, it is observed and noted that the change of pore water pressure when the vibrating liquefaction takes place. Based on relevant suppositions, the equation of wave propagation in saturated granular media is obtained. This paper postulates the potential vector equation and the velocity expression of three kinds of body waves under normal conditions. Utilizing the wave theory and the experimental results, the influence of three body waves on pore water pressure and granules has been analyzed in detail. This revealed the rapid increment mechanism of pore water pressure and the wave mechanism of vibrating liquefaction.

骨炎方治疗骨感染作用机制的实验研究

目的:探讨中药复方骨炎方对家兔慢性骨髓炎的抗炎效应。方法:采用家兔右胫骨骨髓腔内注射金黄色葡萄球菌的方式以诱导慢性骨髓炎模型,动物分为模型组、阳性药克林霉素组(60 mg/kg)、骨炎方两个剂量组(生药量分别为3.6和1.8 g/kg)以及假手术组。各组灌胃给药,分别于给药后第2,4,6周对右胫骨行X线片检查并予诊断分型,采血测定白细胞计数和血沉,取血清测定白介素(IL)-1β,IL-4,IL-6,IL-10等细胞因子含量。结果:骨炎方高剂量组第2,4,6周的X线片诊断分型与模型组比较差异有统计学意义(P<0.01);骨炎方低剂量组第4,6周的X线片诊断分型与模型组比较差异有统计学意义(P<0.05)。与模型组比较,骨炎方高、低剂量组白细胞计数和血沉在给药后第2,4,6周均有明显降低,差异有统计学意义(P<0.05)。与模型组比较,骨炎方高、低剂量组第2,4,6周的促炎细胞因子IL-1β和IL-6水平均有明显降低,差异有统计学意义(P<0.05),第6周的抗炎细胞因子IL-4水平有明显增高,差异有统计学意义(P<0.01);高剂量组抗炎细胞因子IL-10水平则在第4,6周有明显增高,差异有统计学意义(P<0.05)。结论:骨炎方抗家兔慢性骨髓炎的作用机制可能与抑制致病菌、控制炎症反应、恢复促炎/抗炎细胞因子平衡等有关。