Strips of mouse ileum were used in current study to investigate the effect of different concentrations of aspirin on their smooth muscles activities. Student＇s kymograph and glass jacket organ bath were used for reco...Strips of mouse ileum were used in current study to investigate the effect of different concentrations of aspirin on their smooth muscles activities. Student＇s kymograph and glass jacket organ bath were used for recording ilum smooth muscles contractions. The recording of the muscles contractions showed regular autorhythmic pattern, and this contraction was enhanced by both ACh （acetylcholine） and KCI （potassium chloride）. This normal contraction and that induced by ACh and KCI mainly depended on the extracellular calcium in their tension and maintaining. Aspirin exerted different effects on ileal smooth muscles contractions depending upon concentrations. Low concentrations 2-40 mM had an stimulatory effects, while high concentrations 60-200 mM had an inhibitory effects, which led to relaxation. Ca^＋2 free solution abolished muscles response to aspirin with the concentrations caused contractions. Aspirin in tum led to continuation of acetylcholine induced contractions.展开更多
文摘Strips of mouse ileum were used in current study to investigate the effect of different concentrations of aspirin on their smooth muscles activities. Student＇s kymograph and glass jacket organ bath were used for recording ilum smooth muscles contractions. The recording of the muscles contractions showed regular autorhythmic pattern, and this contraction was enhanced by both ACh （acetylcholine） and KCI （potassium chloride）. This normal contraction and that induced by ACh and KCI mainly depended on the extracellular calcium in their tension and maintaining. Aspirin exerted different effects on ileal smooth muscles contractions depending upon concentrations. Low concentrations 2-40 mM had an stimulatory effects, while high concentrations 60-200 mM had an inhibitory effects, which led to relaxation. Ca^＋2 free solution abolished muscles response to aspirin with the concentrations caused contractions. Aspirin in tum led to continuation of acetylcholine induced contractions.
