The AMP-activated protein kinase(AMPK)is a central energy sensor conserved in most eukaryotes[1].It is able to sense acute drops in cellular energy signaled by elevated ratios of AMP/ADP:ATP and respond with a multifa...The AMP-activated protein kinase(AMPK)is a central energy sensor conserved in most eukaryotes[1].It is able to sense acute drops in cellular energy signaled by elevated ratios of AMP/ADP:ATP and respond with a multifaceted approach that increases energy supply,reduces energy consumption,and replenishes cellular energy stock.Bona fide AMPK targets regulate all aspects of glucose,lipid,and amino acid metabolism,as well as autophagy,展开更多
Diabetes is a chronic disease of elevated blood glucose levels that affects more than 400 million people worldwide.Complications of diabetes affect the neuronal and the vascular systems and causes diabetic kidney dise...Diabetes is a chronic disease of elevated blood glucose levels that affects more than 400 million people worldwide.Complications of diabetes affect the neuronal and the vascular systems and causes diabetic kidney disease,cardiovascular disease,hypertension,retinopathy,peripheral neuropathy,and diabetic food diseases.Diabetes is caused by either the body’s inability to展开更多
基金This work was supported by the National Natural Science Foundation of China(31371314 and 81673460)Sichuan Youth Science and Technology Innovation Research Team of Experimental Formulology(2020JDTD0022).
文摘The AMP-activated protein kinase(AMPK)is a central energy sensor conserved in most eukaryotes[1].It is able to sense acute drops in cellular energy signaled by elevated ratios of AMP/ADP:ATP and respond with a multifaceted approach that increases energy supply,reduces energy consumption,and replenishes cellular energy stock.Bona fide AMPK targets regulate all aspects of glucose,lipid,and amino acid metabolism,as well as autophagy,
文摘Diabetes is a chronic disease of elevated blood glucose levels that affects more than 400 million people worldwide.Complications of diabetes affect the neuronal and the vascular systems and causes diabetic kidney disease,cardiovascular disease,hypertension,retinopathy,peripheral neuropathy,and diabetic food diseases.Diabetes is caused by either the body’s inability to
