Interstitial lung disease （ILD） is a comprehensive term referring to a group of lung diseases affecting the interstitium of the lung. Idiopathic pulmonary fibrosis （IPF） is the most common idiopathic ILD, and nons...Interstitial lung disease （ILD） is a comprehensive term referring to a group of lung diseases affecting the interstitium of the lung. Idiopathic pulmonary fibrosis （IPF） is the most common idiopathic ILD, and nonspecific interstitial pneumonia （NSIP） is the second most common. As the name suggests, NSIP is diagnosed atter many other diseases are excluded. The main pathological finding in NSIP is homogeneous interstitial inflammation with or without fibrosis. NSIP can be categorized by cellular type or fibrotic type, according to the grade of inflammation and fibrosis. The cellular type has mostly inflammatory lesions with good responses to steroid, but the fibrotic type has a large proportion of fibrosis mixed with inflammatory lesions and a relatively poor response to steroid treatment So far, the exact mechanism underlying idiopathic lED has not been clarified. Determining key regulators of these ILDs will be helpful in the diagnosis and development of novel drugs for ILD.展开更多
To the Editor：The anti-tuberculosis （TB） therapy can cause various drug adverse effects including hepatotoxicity,nephrotoxicity and skin rash.[1,2] There are some case reports about interstitial lung disease （ILD...To the Editor：The anti-tuberculosis （TB） therapy can cause various drug adverse effects including hepatotoxicity,nephrotoxicity and skin rash.[1,2] There are some case reports about interstitial lung disease （ILD） such as pneumonitis caused by isoniazid （INH）,rifampin （RFP）,ethambutol （EMB）.展开更多
文摘Interstitial lung disease （ILD） is a comprehensive term referring to a group of lung diseases affecting the interstitium of the lung. Idiopathic pulmonary fibrosis （IPF） is the most common idiopathic ILD, and nonspecific interstitial pneumonia （NSIP） is the second most common. As the name suggests, NSIP is diagnosed atter many other diseases are excluded. The main pathological finding in NSIP is homogeneous interstitial inflammation with or without fibrosis. NSIP can be categorized by cellular type or fibrotic type, according to the grade of inflammation and fibrosis. The cellular type has mostly inflammatory lesions with good responses to steroid, but the fibrotic type has a large proportion of fibrosis mixed with inflammatory lesions and a relatively poor response to steroid treatment So far, the exact mechanism underlying idiopathic lED has not been clarified. Determining key regulators of these ILDs will be helpful in the diagnosis and development of novel drugs for ILD.
文摘To the Editor：The anti-tuberculosis （TB） therapy can cause various drug adverse effects including hepatotoxicity,nephrotoxicity and skin rash.[1,2] There are some case reports about interstitial lung disease （ILD） such as pneumonitis caused by isoniazid （INH）,rifampin （RFP）,ethambutol （EMB）.
