Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens.Its effective use as a cancer therapy requires a precisely targeted approach,which can be fa...Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens.Its effective use as a cancer therapy requires a precisely targeted approach,which can be facilitated by using nanoparticles and nanomedicine,and their use to enhance ferroptosis is indeed a growing area of research.While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles,there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine.Furthermore,magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging(MRI).The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine.Here,recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized.This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine.Finally,image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations.展开更多
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(No.RS-2023-00208427)a Korea University Grant.This work was also supported by National Cancer Institute(NCI)grant(No.R01CA218659)National Institute of Biomedical Imaging and Bioengineering(NIBIB)grant(No.R01EB026207)。
文摘Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens.Its effective use as a cancer therapy requires a precisely targeted approach,which can be facilitated by using nanoparticles and nanomedicine,and their use to enhance ferroptosis is indeed a growing area of research.While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles,there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine.Furthermore,magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging(MRI).The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine.Here,recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized.This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine.Finally,image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations.
