The impact of different iron metabolism processes(DIMP)on ovarian cancer remains unclear.In this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ...The impact of different iron metabolism processes(DIMP)on ovarian cancer remains unclear.In this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian cancer.cBioPortal was used to determine mutations in DIMP-associated genes in ovarian cancer.Kaplan-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian cancer.By analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation process.Compared to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian cancer.Furthermore,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was increased.In addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free survival.Additionally,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited after TGF-β1 or TGF-β2 treatment.In conclusion,DIMP plays multifaceted roles in the initiation,chemo-resistance,and prognosis of ovarian cancer.Therapeutically targeting DIMP may pave the way for more tailored treatment approaches for ovarian cancer.展开更多
China Geodetic Coordinate System 2000(CGCS2000)has been used for several years as a formal published reference frame.The coordinates of all global navigation satellite system(GNSS)stations in China need to be correcte...China Geodetic Coordinate System 2000(CGCS2000)has been used for several years as a formal published reference frame.The coordinates of all global navigation satellite system(GNSS)stations in China need to be corrected to align with the CGCS2000 frame.Different strategies can be adopted for the realization of an optimal reference frame.However,different strategies lead to different results,with differences as great as several decimeters when GNSS station coordinates are transformed into CGCS2000-defined coordinates.The two common methods for the coordinate correction of a GNSS station are quasi-stable adjustment under CGCS2000 and plate movement correction,and the differences between their results can be greater than 10 cm.In this study,a statistic method called"supervised clustering"is applied to the selection of GNSS reference stations;a new scheme named"partition spacing"for the grouping of all processed GNSS stations is proposed;and the plate movement correction method is used to correct the coordinates of all GNSS stations from the GNSS epoch to the CGCS2000 epoch.The results from the new partitioning method were found to be significantly better than those from the conventional station-blocking approach.When coordinates from the stations without grouping were used as the standard,the accuracy of all the three-dimensional coordinate components from the new partitioning method was better than 2 mm.The root mean squares(RMSs)of the velocities in the x,y,and z directions resulting from the supervised clustering method were 0.19,0.45,and 0.32 mm∙a1,respectively,which were much smaller than the values of 0.92,0.72,and 0.97 mm∙a1 that resulted from the conventional approach.In addition,singular spectrum analysis(SSA)was used to model and predict the position nonlinear movements.The modeling accuracies of SSA were better than 3,2,and 5 mm in the east(E),north(N),and up(U)directions,respectively;and its prediction accuracies were better than 5 mm and 1 cm for the horizontal and vertical domains,respectively.展开更多
The rate of the total electron content(TEC)change index(ROTI)can be regarded as an effective indicator of the level of ionospheric scintillation,in particular in low and high latitude regions.An accurate prediction of...The rate of the total electron content(TEC)change index(ROTI)can be regarded as an effective indicator of the level of ionospheric scintillation,in particular in low and high latitude regions.An accurate prediction of the ROTI is essential to reduce the impact of the ionospheric scintillation on earth observation systems,such as the global navigation satellite systems.However,it is difficult to predict the ROTI with high accuracy because of the complexity of the ionosphere.In this study,advanced machine learning methods have been investigated for ROTI prediction over a station at high-latitude in Canada.These methods are used to predict the ROTI in the next 5 minutes using the data derived from the past 15 minutes at the same location.Experimental results show that the method of the bidirectional gated recurrent unit network(BGRU)outperforms the other six approaches tested in the research.It is also confirmed that the RMSEs of the predicted ROTI using the BGRU method in all four seasons of 2017 are less than 0.05 TECU/min.It is demonstrated that the BGRU method exhibits a high level of robustness in dealing with abrupt solar activities.展开更多
Due to the poor Fenton reactivity,single-atom Mn-based materials are generally identified as one of the most promising active catalysts for oxygen reduction reaction(ORR).Regulating the electronic density and coordina...Due to the poor Fenton reactivity,single-atom Mn-based materials are generally identified as one of the most promising active catalysts for oxygen reduction reaction(ORR).Regulating the electronic density and coordination environment of atomically dispersed Mn centers is an effective strategy to enhance ORR activity of Mn-based materials.By introducing Zn sites,atomically dispersed Mn centers with multitudes of coordination(including Zn/Mn–Nx and Mn–Nx moieties)can be constructed to form Mn-based ORR catalyst(Zn/Mn-NC)with dual-atom sites.Around Mn–Nx sites,the Zn atoms can effectively modulate the electronic structure and coordination state of Mn centers in Zn/Mn-NC through d–d orbital coupling.The electronic interaction between Zn and Mn sites improves ORR activity,thereby optimizing the oxygen adsorption energy of Mn sites in Zn/Mn-NC and reducing the overall energy barrier.Zn/Mn-NC displays higher ORR half-wave potential than Pt/C(0.89 V vs 0.86 V).The quasi-solid-state zinc-air battery(ZAB)with Zn/Mn-NC as the cathode displayed excellent rechargeability,recyclability,and mechanical robustness.The strategy presented regulates the electronic density and coordination environment of singleatom Mn-based ORR catalysts in quasi-solid-state ZABs.展开更多
With the increasing demand for energy, various emerging energy storage/conversion technologies have gradually penetrated human life, providing numerous conveniences. The practical application efficiency is often affec...With the increasing demand for energy, various emerging energy storage/conversion technologies have gradually penetrated human life, providing numerous conveniences. The practical application efficiency is often affected by the slow kinetics of hydrogen or oxygen electrocatalytic reactions(hydrogen evolution and oxidation reactions, oxygen evolution and reduction reactions) among the emerging devices. Therefore, the researchers devote to finding cost-effective electrocatalysts. Non-noble metal catalysts have low cost and good catalytic activity, but poor stability, agglomeration, dissolution, and other problems will occur after a long cycle, such as transition metal oxides and carbides. Transition metal nitrides(TMNs) stand out among all kinds of non-noble metal catalysts because of the intrinsic platinum-like electrocatalytic activities, relatively high conductivity, and wide range of tunability. In this review, the applications of TMNs in electrocatalytic fields are summarized based on the number of metals contained in TMNs. The practical application potentials of TMNs in fuel cell, water splitting, zinc-air battery and other electrochemical energy storage/conversion devices are also listed. Finally, the design strategies and viewpoints of TMNs-based electrocatalyst are summarized. The potential challenges of TMNs-based electrocatalyst in the development of electrocatalytic energy devices in the future are prospected.展开更多
基金supported by Academic Leader Training Program of Pudong New Area Health System in Shanghai(Grant No.PWRd2021-13).
文摘The impact of different iron metabolism processes(DIMP)on ovarian cancer remains unclear.In this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian cancer.cBioPortal was used to determine mutations in DIMP-associated genes in ovarian cancer.Kaplan-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian cancer.By analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation process.Compared to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian cancer.Furthermore,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was increased.In addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free survival.Additionally,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited after TGF-β1 or TGF-β2 treatment.In conclusion,DIMP plays multifaceted roles in the initiation,chemo-resistance,and prognosis of ovarian cancer.Therapeutically targeting DIMP may pave the way for more tailored treatment approaches for ovarian cancer.
基金This study is supported by the National Key Research and Development Program of China(2016YFB0501405)Natural Resources Innovation Platform Construction and Capacity Improvement(A19090)The Fundamental Research Funds for Chinese Academy of Surveying and Mapping(AR1903 and AR2005).
文摘China Geodetic Coordinate System 2000(CGCS2000)has been used for several years as a formal published reference frame.The coordinates of all global navigation satellite system(GNSS)stations in China need to be corrected to align with the CGCS2000 frame.Different strategies can be adopted for the realization of an optimal reference frame.However,different strategies lead to different results,with differences as great as several decimeters when GNSS station coordinates are transformed into CGCS2000-defined coordinates.The two common methods for the coordinate correction of a GNSS station are quasi-stable adjustment under CGCS2000 and plate movement correction,and the differences between their results can be greater than 10 cm.In this study,a statistic method called"supervised clustering"is applied to the selection of GNSS reference stations;a new scheme named"partition spacing"for the grouping of all processed GNSS stations is proposed;and the plate movement correction method is used to correct the coordinates of all GNSS stations from the GNSS epoch to the CGCS2000 epoch.The results from the new partitioning method were found to be significantly better than those from the conventional station-blocking approach.When coordinates from the stations without grouping were used as the standard,the accuracy of all the three-dimensional coordinate components from the new partitioning method was better than 2 mm.The root mean squares(RMSs)of the velocities in the x,y,and z directions resulting from the supervised clustering method were 0.19,0.45,and 0.32 mm∙a1,respectively,which were much smaller than the values of 0.92,0.72,and 0.97 mm∙a1 that resulted from the conventional approach.In addition,singular spectrum analysis(SSA)was used to model and predict the position nonlinear movements.The modeling accuracies of SSA were better than 3,2,and 5 mm in the east(E),north(N),and up(U)directions,respectively;and its prediction accuracies were better than 5 mm and 1 cm for the horizontal and vertical domains,respectively.
基金National Key Research Program of China(No.2017YFE0131400)National Natural Science Foundation of China(Nos.41674043,41704038,41874040)+2 种基金Beijing Nova Program(No.xx2017042)Beijing Talents Foundation(No.2017000021223ZK13)CUMT Independent Innovation Project of“Double-First Class”Construction(No.2018ZZ08)。
文摘The rate of the total electron content(TEC)change index(ROTI)can be regarded as an effective indicator of the level of ionospheric scintillation,in particular in low and high latitude regions.An accurate prediction of the ROTI is essential to reduce the impact of the ionospheric scintillation on earth observation systems,such as the global navigation satellite systems.However,it is difficult to predict the ROTI with high accuracy because of the complexity of the ionosphere.In this study,advanced machine learning methods have been investigated for ROTI prediction over a station at high-latitude in Canada.These methods are used to predict the ROTI in the next 5 minutes using the data derived from the past 15 minutes at the same location.Experimental results show that the method of the bidirectional gated recurrent unit network(BGRU)outperforms the other six approaches tested in the research.It is also confirmed that the RMSEs of the predicted ROTI using the BGRU method in all four seasons of 2017 are less than 0.05 TECU/min.It is demonstrated that the BGRU method exhibits a high level of robustness in dealing with abrupt solar activities.
基金support of the National Natural Science Foundation of China(grant nos.22278193 and 22178148)Jiangsu Province and Education Ministry Cosponsored Synergistic Innovation Center of Modern Agricultural Equipment(grant no.XTCX2029)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Due to the poor Fenton reactivity,single-atom Mn-based materials are generally identified as one of the most promising active catalysts for oxygen reduction reaction(ORR).Regulating the electronic density and coordination environment of atomically dispersed Mn centers is an effective strategy to enhance ORR activity of Mn-based materials.By introducing Zn sites,atomically dispersed Mn centers with multitudes of coordination(including Zn/Mn–Nx and Mn–Nx moieties)can be constructed to form Mn-based ORR catalyst(Zn/Mn-NC)with dual-atom sites.Around Mn–Nx sites,the Zn atoms can effectively modulate the electronic structure and coordination state of Mn centers in Zn/Mn-NC through d–d orbital coupling.The electronic interaction between Zn and Mn sites improves ORR activity,thereby optimizing the oxygen adsorption energy of Mn sites in Zn/Mn-NC and reducing the overall energy barrier.Zn/Mn-NC displays higher ORR half-wave potential than Pt/C(0.89 V vs 0.86 V).The quasi-solid-state zinc-air battery(ZAB)with Zn/Mn-NC as the cathode displayed excellent rechargeability,recyclability,and mechanical robustness.The strategy presented regulates the electronic density and coordination environment of singleatom Mn-based ORR catalysts in quasi-solid-state ZABs.
基金supported by the Natural Science Foundation of Jiangsu Province (No. BK20191430)Six Talent Peaks Project in Jiangsu Province (No. XNY-009)+2 种基金High-tech Research Key Laboratory of Zhenjiang (No. SS2018002)Jiangsu Province Key Laboratory of Intelligent Building Energy Efficiency (No. BEE201904)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘With the increasing demand for energy, various emerging energy storage/conversion technologies have gradually penetrated human life, providing numerous conveniences. The practical application efficiency is often affected by the slow kinetics of hydrogen or oxygen electrocatalytic reactions(hydrogen evolution and oxidation reactions, oxygen evolution and reduction reactions) among the emerging devices. Therefore, the researchers devote to finding cost-effective electrocatalysts. Non-noble metal catalysts have low cost and good catalytic activity, but poor stability, agglomeration, dissolution, and other problems will occur after a long cycle, such as transition metal oxides and carbides. Transition metal nitrides(TMNs) stand out among all kinds of non-noble metal catalysts because of the intrinsic platinum-like electrocatalytic activities, relatively high conductivity, and wide range of tunability. In this review, the applications of TMNs in electrocatalytic fields are summarized based on the number of metals contained in TMNs. The practical application potentials of TMNs in fuel cell, water splitting, zinc-air battery and other electrochemical energy storage/conversion devices are also listed. Finally, the design strategies and viewpoints of TMNs-based electrocatalyst are summarized. The potential challenges of TMNs-based electrocatalyst in the development of electrocatalytic energy devices in the future are prospected.
