Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC...Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC） and explore their clinical significance. Methods： The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical （IHC） staining and periodic acid-Schiff （PAS） reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results： PPARy was over-expressed （24/34） in HCC tissues, it was associated with tumor size （〉 5 cm, P = 0.027）, broken capsule （P = 0.014）, tendency to metastasis and recurrence （P = 0.001）. The MVD was higher （23/24） in HCC tissues than that in corresponding para-cancerous tissues （t = 18.925, P 〈 0.05）. There was a significant positive correlation between the over-expression of PPARy and high MVD （r = 0.519）. Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients （P = 0.013, 0.036 and 0.022, respectively; log-rank test）. Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC. Conclusion： The PPARy correlated with the development of microcirculatory in HCC. PPARy is a novel prognostic indicator for evaluating of HCC.展开更多
The influences of reheating duration on microstructures and tensile properties of thixoforged in situ Mg2Sip/ AM60B composites have been investigated. The results indicate that the reheating time affects the volume fr...The influences of reheating duration on microstructures and tensile properties of thixoforged in situ Mg2Sip/ AM60B composites have been investigated. The results indicate that the reheating time affects the volume fraction, composition and distribution of the liquid phase, the evolution of the liquid pools within the primary particles, and the morphology and distribution of the Mg2Si particles of the semisolid feedstock. These changes then affect the subsequent solidification behavior and deformation mechanism during thixoforging, which are responsible for the resulting micro- structure and tensile properties. Mg2Si particles play a strengthening role for the matrix through the load transfer mechanism. The appropriate reheating time is 60 min at 600 ℃ when the mold preheating temperature is at 300 ℃. The ultimate tensile strength and elongation of the resulting composite are up to 209 MPa and 11.9%, respectively.展开更多
文摘Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC） and explore their clinical significance. Methods： The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical （IHC） staining and periodic acid-Schiff （PAS） reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results： PPARy was over-expressed （24/34） in HCC tissues, it was associated with tumor size （〉 5 cm, P = 0.027）, broken capsule （P = 0.014）, tendency to metastasis and recurrence （P = 0.001）. The MVD was higher （23/24） in HCC tissues than that in corresponding para-cancerous tissues （t = 18.925, P 〈 0.05）. There was a significant positive correlation between the over-expression of PPARy and high MVD （r = 0.519）. Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients （P = 0.013, 0.036 and 0.022, respectively; log-rank test）. Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC. Conclusion： The PPARy correlated with the development of microcirculatory in HCC. PPARy is a novel prognostic indicator for evaluating of HCC.
文摘The influences of reheating duration on microstructures and tensile properties of thixoforged in situ Mg2Sip/ AM60B composites have been investigated. The results indicate that the reheating time affects the volume fraction, composition and distribution of the liquid phase, the evolution of the liquid pools within the primary particles, and the morphology and distribution of the Mg2Si particles of the semisolid feedstock. These changes then affect the subsequent solidification behavior and deformation mechanism during thixoforging, which are responsible for the resulting micro- structure and tensile properties. Mg2Si particles play a strengthening role for the matrix through the load transfer mechanism. The appropriate reheating time is 60 min at 600 ℃ when the mold preheating temperature is at 300 ℃. The ultimate tensile strength and elongation of the resulting composite are up to 209 MPa and 11.9%, respectively.
