Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods ...Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package （EPP） model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% （95% CI：0.042%,0.108%） in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% （95% CI：0.070%,0.150%） by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population.展开更多
The zinc finger transcription factor, Ikaros, is a central regulator of hematopoiesis. It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell recepto...The zinc finger transcription factor, Ikaros, is a central regulator of hematopoiesis. It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptors expression. Mature B cells rely on Ikaros to set the activation threshold for various stimuli, and to choose the correct antibody isotype during class switch recombination. Thus, Ikaros contributes to nearly every level of B cell differentiation and function.展开更多
Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene.Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemi...Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene.Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.In particular,Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.Its role in T-cell leukemia,however,has been more controversial.While Ikaros deficiency appears to be very frequent in murine T-cell leukemias,loss of Ikaros appears to be rare in human T-cell acute lymphoblastic leukemia (T-ALL).We review here the evidence linking Ikaros to T-ALL in mouse and human systems.展开更多
文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package （EPP） model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% （95% CI：0.042%,0.108%） in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% （95% CI：0.070%,0.150%） by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population.
基金Supported by La Ligue Contre le Cancer (équipe labellisée),l’ Agence Nationale de la Recherche and La Fondation pour la Recherche Médicale,with institute funding from INSERM,CNRS and l’Université de Strasbourg
文摘The zinc finger transcription factor, Ikaros, is a central regulator of hematopoiesis. It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptors expression. Mature B cells rely on Ikaros to set the activation threshold for various stimuli, and to choose the correct antibody isotype during class switch recombination. Thus, Ikaros contributes to nearly every level of B cell differentiation and function.
基金Supported by Institut National du Cancer,La Ligue Contre le Cancer (équipe labellisée),l’Agence Nationale de la Recherche,l’Association pour la Recherche sur le Cancer and La Fondation de France,with institute funding from INSERM,CNRS and l’ Université de Strasbourg
文摘Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene.Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.In particular,Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.Its role in T-cell leukemia,however,has been more controversial.While Ikaros deficiency appears to be very frequent in murine T-cell leukemias,loss of Ikaros appears to be rare in human T-cell acute lymphoblastic leukemia (T-ALL).We review here the evidence linking Ikaros to T-ALL in mouse and human systems.
