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Construction and expression of retroviruses encoding dual drug resistance genes in human umbilical cord blood CD34^+ cells 被引量:2
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作者 susane.kane 《Chinese Science Bulletin》 SCIE EI CAS 2000年第15期1390-1394,共5页
A series of retroviral vectors encoding human mdrl gene alone as well as in combination with either human mgmt gene or human mutant Ser31-dftfrgene are engineered. The resultant retroviruses are used to transduce huma... A series of retroviral vectors encoding human mdrl gene alone as well as in combination with either human mgmt gene or human mutant Ser31-dftfrgene are engineered. The resultant retroviruses are used to transduce human umbilical cord blood CD34+ cells. It has been shown that expression of dual drug resistance genes in transduced cells confers a broad range of resistance to both kinds of corresponding drugs. These data suggest a rationale for the use of such double chemoresistance gene constructs in an in vivo model in which transduced hematopoietic cells will acquire multiple protection against the cytotoxic side effects of combination chemotherapy and may have future application in chemoprotection of normal tissues, thus killing tumor cells more effectively. 展开更多
关键词 tumor CHEMOTHERAPY RETROVIRUS drug resistance gene CORD blood CD34+ cells.
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