Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic strategies.In particular,neuropathic pain is a very ...Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic strategies.In particular,neuropathic pain is a very frequent sequel of spinal cord injury（SCI）and a decisive contributor to decreased quality of life.展开更多
Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransm...Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransmission dysfunctions.Over the past decades,valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders,which usually overlap and critically contribute to long-term disability.However,up to now,no definite cures or effective disease-modifying therapies are available for any of these conditions.This has led to an active search of novel therapeutic approaches,including the repositioning of existing drugs for new indications,as a valid approach to promptly move candidate molecules to clinical trials.展开更多
基金partly supported by grants from CONICET(PIP201-101-00576)Fundación RenéBarón
文摘Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic strategies.In particular,neuropathic pain is a very frequent sequel of spinal cord injury（SCI）and a decisive contributor to decreased quality of life.
基金supported by grants from Consejo Nacional de Investigaciones Científicas y Tecnológicas(CONICET,PIP 112-201501-00266)Agencia Nacional de Promoción Científica y Técnica(PICT 2018-02152)Fundación RenéBarón and Fundación Williams
文摘Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransmission dysfunctions.Over the past decades,valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders,which usually overlap and critically contribute to long-term disability.However,up to now,no definite cures or effective disease-modifying therapies are available for any of these conditions.This has led to an active search of novel therapeutic approaches,including the repositioning of existing drugs for new indications,as a valid approach to promptly move candidate molecules to clinical trials.
