Neisseria meningitidis is a gram-negative diplococcus which causes invasive disease. The most frequent clinical manifestations caused by infection with this pathogen, are meningitis and fulminant septic shock. More be...Neisseria meningitidis is a gram-negative diplococcus which causes invasive disease. The most frequent clinical manifestations caused by infection with this pathogen, are meningitis and fulminant septic shock. More benign forms with a subacute or chronic pattern are rare but still can evolve to meningitis and have a fatal outcome. This entity is difficult to recognize, as febrile erythema with otherwise good general condition may simulate other diseases, namely viral infections. The authors reported the cases of two healthy young adults who were misdiagnosed with a viral infection. What they really had was a meningococcemia without meningitis presenting with mild and unspecific symptoms, such as, intermittent fever and a discrete macular rash. We pretend to highlight this rare, unspecific and heterogeneous symptoms which can provoke negligence of a potentially life threatening condition.展开更多
Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relati...Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relatively safe;however, occasionally BCG infection complicates such treatment. In the present work we describe three patients in whom BCG infection occurred after intravesical BCG therapy. All patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult and microbiologic study is usually negative, so high index of suspicion is essential.展开更多
The proposed technique demonstrates a fiber ring resonator interrogated by an optical time domain reflectometer(OTDR),for intensity sensing.By using this methodology,a cavity round trip time of 2.85ms was obtained.For...The proposed technique demonstrates a fiber ring resonator interrogated by an optical time domain reflectometer(OTDR),for intensity sensing.By using this methodology,a cavity round trip time of 2.85ms was obtained.For a proof of concept,a long-period grating was inserted in the resonant cavity operating as a curvature sensing device.A novel signal processing approach was outlined,regarding to the logarithmic behavior of the OTDR.Through analyzing the experimental results,an increase in the measured sensitivities was obtained by increasing applied bending.With curvatures performed from 1.8 m^(-1) to 4.5 m^(-1),the sensitivity values ranged from 2.94 dB·km^(-1) to 5.15 dB·km^(-1).In its turn,the sensitivities obtained presented a linear behavior when studied as a function of the applied curvature,following a slope of 0.86×10-3 dB.The advantages of applying this technique were also discussed,demonstrating two similar fiber rings multiplexed in a series of configurations.展开更多
文摘Neisseria meningitidis is a gram-negative diplococcus which causes invasive disease. The most frequent clinical manifestations caused by infection with this pathogen, are meningitis and fulminant septic shock. More benign forms with a subacute or chronic pattern are rare but still can evolve to meningitis and have a fatal outcome. This entity is difficult to recognize, as febrile erythema with otherwise good general condition may simulate other diseases, namely viral infections. The authors reported the cases of two healthy young adults who were misdiagnosed with a viral infection. What they really had was a meningococcemia without meningitis presenting with mild and unspecific symptoms, such as, intermittent fever and a discrete macular rash. We pretend to highlight this rare, unspecific and heterogeneous symptoms which can provoke negligence of a potentially life threatening condition.
文摘Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relatively safe;however, occasionally BCG infection complicates such treatment. In the present work we describe three patients in whom BCG infection occurred after intravesical BCG therapy. All patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult and microbiologic study is usually negative, so high index of suspicion is essential.
基金This work is financed by National Funds through the Portuguese funding agency,FCT-“Fundação para a Ciência e a Tecnologia”under Grant No.UID/EEA/50014/2019.
文摘The proposed technique demonstrates a fiber ring resonator interrogated by an optical time domain reflectometer(OTDR),for intensity sensing.By using this methodology,a cavity round trip time of 2.85ms was obtained.For a proof of concept,a long-period grating was inserted in the resonant cavity operating as a curvature sensing device.A novel signal processing approach was outlined,regarding to the logarithmic behavior of the OTDR.Through analyzing the experimental results,an increase in the measured sensitivities was obtained by increasing applied bending.With curvatures performed from 1.8 m^(-1) to 4.5 m^(-1),the sensitivity values ranged from 2.94 dB·km^(-1) to 5.15 dB·km^(-1).In its turn,the sensitivities obtained presented a linear behavior when studied as a function of the applied curvature,following a slope of 0.86×10-3 dB.The advantages of applying this technique were also discussed,demonstrating two similar fiber rings multiplexed in a series of configurations.
