In this study, we report a novel and facile autoclave strategy for synthesis of near-infrared （NIR） CulnS2 QDs by employing glutathione （GSH） as capping ligand and stabilizer in aqueous media under 100 ~C. Various...In this study, we report a novel and facile autoclave strategy for synthesis of near-infrared （NIR） CulnS2 QDs by employing glutathione （GSH） as capping ligand and stabilizer in aqueous media under 100 ~C. Various experi- mental parameters including the ratio of precursors, reaction time, reaction temperature, pH effect and stability have been systematically studied. The QDs were characterized by X-ray diffraction （XRD）, transmission electron micro- scope （TEM）, and Fourier transform infrared spectroscopy （FT-IR）. The as-synthesized NIR QDs exhibited low cytotoxicity and maintained excellent cell viability even up to 100 gg/mL. After bioconjugation with Arg-Gly-Asp （RGD） peptide, the obtained CulnS2-RGD QDs have demonstrated high targeting ability with good fluorescence cell imaging performance.展开更多
A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection.In solution,the fluorescent probe displayed a strong fluo...A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection.In solution,the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose,and an expected trend in apparent binding constants,as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>D-glucose.The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement(≤0.25 mol/L).展开更多
It is known that the localized surface plasmon resonance(LSPR) wavelength of plasmonics is highly dependent on compositions and geometry of plasmonics as well as the surrounding environments. Here, monodispersed Au@Ag...It is known that the localized surface plasmon resonance(LSPR) wavelength of plasmonics is highly dependent on compositions and geometry of plasmonics as well as the surrounding environments. Here, monodispersed Au@Ag core-shell nanoparticles(Au@Ag NPs) were prepared by carefully optimizing the shell thickness of Au@Ag NPs, and the presence of hydrogen sulfide(H_2 S) would significantly alter the LSPR wavelength. On the basis of this, a photothermal paper sensor for on-site recognition of H_2 S was constructed with a visual detection limit of 12.8 ng/L.展开更多
Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the com...Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of I9F magnetic resonance imaging （19F MRI） and fluorescence imaging （FI） into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne-terminated fluorinated copolymer （Pn） of 2,2,2-trifluoroethyl acrylate （TFEA） and poly（ethylene glycol） methyl ether acrylate （PEGA） was first prepared vie atom transfer radical polymerization （ATRP）. The PEGA plays an important role in both improving ^19F signal and modulating the hydrophilicity of Pn. The alkynyl tail in Pn is readily conjugated with azide modified tetra-phenylethylene （TPE） through click chemistry to form azo polymer （TPE-azo-Pn）. The core-shell nanoprobes （TPE-P3N） with an average particle size of 57.2±8.8 nm are obtained via self-assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good ^19F MRI performance, which present great potentials for simultaneous fluorescence imaging and ^19F-MR imaging.展开更多
文摘In this study, we report a novel and facile autoclave strategy for synthesis of near-infrared （NIR） CulnS2 QDs by employing glutathione （GSH） as capping ligand and stabilizer in aqueous media under 100 ~C. Various experi- mental parameters including the ratio of precursors, reaction time, reaction temperature, pH effect and stability have been systematically studied. The QDs were characterized by X-ray diffraction （XRD）, transmission electron micro- scope （TEM）, and Fourier transform infrared spectroscopy （FT-IR）. The as-synthesized NIR QDs exhibited low cytotoxicity and maintained excellent cell viability even up to 100 gg/mL. After bioconjugation with Arg-Gly-Asp （RGD） peptide, the obtained CulnS2-RGD QDs have demonstrated high targeting ability with good fluorescence cell imaging performance.
基金grateful for the support of the EPSRC and DTI(DT/F00267X/1)the Leverhulme Trust for support(F00094BC)the JDRF(2-SRA-2016-267-A-N)for support.
文摘A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection.In solution,the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose,and an expected trend in apparent binding constants,as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>D-glucose.The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement(≤0.25 mol/L).
基金supported by the National Natural Science Foundation of China(21725501,21475007,21675009,21505003)the Fundamental Research Funds for the Central Universities(buctrc201706,buctrc201720)
文摘It is known that the localized surface plasmon resonance(LSPR) wavelength of plasmonics is highly dependent on compositions and geometry of plasmonics as well as the surrounding environments. Here, monodispersed Au@Ag core-shell nanoparticles(Au@Ag NPs) were prepared by carefully optimizing the shell thickness of Au@Ag NPs, and the presence of hydrogen sulfide(H_2 S) would significantly alter the LSPR wavelength. On the basis of this, a photothermal paper sensor for on-site recognition of H_2 S was constructed with a visual detection limit of 12.8 ng/L.
基金This research was supported Science Foundation of China 21675009）, and the Fundamenta n part by the National Natural （Grant Nos. 21475007 and Research Funds for the Central Universities （buctrc201608 and buctrc201720）.
文摘Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of I9F magnetic resonance imaging （19F MRI） and fluorescence imaging （FI） into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne-terminated fluorinated copolymer （Pn） of 2,2,2-trifluoroethyl acrylate （TFEA） and poly（ethylene glycol） methyl ether acrylate （PEGA） was first prepared vie atom transfer radical polymerization （ATRP）. The PEGA plays an important role in both improving ^19F signal and modulating the hydrophilicity of Pn. The alkynyl tail in Pn is readily conjugated with azide modified tetra-phenylethylene （TPE） through click chemistry to form azo polymer （TPE-azo-Pn）. The core-shell nanoprobes （TPE-P3N） with an average particle size of 57.2±8.8 nm are obtained via self-assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good ^19F MRI performance, which present great potentials for simultaneous fluorescence imaging and ^19F-MR imaging.
