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CD4和CD8细胞毒性T淋巴细胞在病毒性水疱形成中的作用
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作者 Morizane S. suzuki d. +1 位作者 Tsuji K. 焦婷 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第2期33-34,共2页
Background: Herpetic vesicles caused by herpes simplex virus and varicella zoster virus, and hydroa vacciniforme (HV) are characterized by umbilicated vesicule formation. Objectives: To understand the histogenesis of ... Background: Herpetic vesicles caused by herpes simplex virus and varicella zoster virus, and hydroa vacciniforme (HV) are characterized by umbilicated vesicule formation. Objectives: To understand the histogenesis of umbilicated vesicles in herpetic vesicles and HV, we demonstrated the presence of the virus- associated molecules in the lesions, and the pathogenic role of cytotoxic T- lymphocyte (CTL) immune responses. Methods: Phenotyping of infiltrating cells was carried out in biopsy specimens from herpes simplex, varicella, herpes zoster and HV, and compared with nonviral contact dermatitis. Viral antigens and Epstein- Barr virus- encoded small nuclear RNA (EBER) were detected by immunostaining and by in situ hybridization, respectively. Infiltrating CTLs expressing granzyme B and granulysin were determined by double immunostaining using confocal laser scanning microscopy. Results: In all herpetic vesicles, the corresponding viral antigens were observed in the cytopathic keratinocytes, and infiltration of lymphoid cells was present in the upper dermis and around the vessels. In all HV lesions studied, EBER+ T cells made up 5- 10% of the dermal infiltrates and the dermal infiltrates contained almost no CD56 cells. CTLs expressing granzyme B and granulysin were present in both herpetic and HV lesions, in which they made up 10- 30% of the total dermal infiltrates, whereas they comprised less than 5% of the infiltrates of biopsy specimens from nonviral contact dermatitis. Confocal laser microscopic examination demonstrated that both CD4+ and CD8+ T cells expressed granzyme B and granulysin. Conclusions: CD4+ and/or CD8+ CTLs reactive to the virus- infected cells might be responsible for the histogenesis of herpetic and HV lesions characterized by umbilicated vesicles. 展开更多
关键词 水疱形成 CD4 CD8 细胞毒性 脐凹 粒酶 牛痘样水疱病 浸润细胞 疱疹性 真皮浅层
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