The non-marine Cretaceous-Paleogene boundary(KPgB)in Jiayin of Heilongjiang was first defined and reported in China by the authors research team in 2011.Thereafter the continuous research on the KPgB and its related L...The non-marine Cretaceous-Paleogene boundary(KPgB)in Jiayin of Heilongjiang was first defined and reported in China by the authors research team in 2011.Thereafter the continuous research on the KPgB and its related Late Cretaceous biota in Jiayin has been made by the authors in 2012-2020.The achievements of the research are mainly reflected as follows:(1)a new drilling borehole with 60 m in depth carried out in the Xiaoheyan of Jiayin in 2016,supplemented new palynological evidence for the KPgB definition in 2011;(2)some radiometric dating newly made on the strata related to the KPgB in Jiayin and its neighboring Russian area,provided the supplemental evidence for the KPgB definition in Jiayin;(3)many new fossils found by the authors,represented by the angiosperms Dalembia and Nelumbo,refresh understanding the Late Cretaceous environment of Jiayin;and(4)the TEM method is applied in the study of pollen exine ultrastructure of Pseudointegricorpus,Wodehouseia,and Aquilapollenites,promoting the late Maastrichtian ecological study in Jiayin,related to the KPgB.展开更多
Background:This study was carried out to clarify the etiology and clinicopathological features of hepatocellular carcinomas (HCCs) arising in patients without chronic viral infection or alcohol abuse. Methods:HCC pati...Background:This study was carried out to clarify the etiology and clinicopathological features of hepatocellular carcinomas (HCCs) arising in patients without chronic viral infection or alcohol abuse. Methods:HCC patients who underwent resection were divided into three groups:a non-B non-C (NBNC) group (n = 13), who were seronegative for hepatitis B surface antigen (HBs Ag) and anti-hepatitis C antibody (HCV Ab), excluding a history of alcohol abuse; a B group (n = 25), who were seropositive for HBs Ag only; and a C group (n = 116), who were seropositive for HCV Ab only. We analyzed the features of tumor-and host-related factors and the outcome of the NBNC group. Results:Hepatic inflammation and fibrosis were less severe in the NBNC group than in the other groups. There were no significant differences in tumor-related factors, except for higher serum levels of α-fetoprotein in the NBNC group. Recurrence rates and disease-free survivals were comparable among the three groups. The NBNC group comprised a greater population with one or two recurrent hepatic lesions (P < 0.05), and indocyanine green retention rates and fibrosis scores were preserved after the initial hepatectomy. The NBNC group had higher resection rates for intrahepatic recurrences (75.0%) than the other groups (21.1%and 22.2%in groups B and C, respectively; P < 0.05 and P < 0.05). The survival rate after the initial hepatectomy or detection of the recurrent lesions was significantly better in the NBNC group (both 100%at 5 years) than those in groups B and C (P < 0.05). Conclusions:NBNC patients maintained good liver function following the initial hepatectomy, and tended to have one or two recurrent lesions. These biological advantages provided NBNC patients more opportunities for repeat resection of intrahepatic recurrences, which may lead to a favorable outcome.展开更多
基金supports of the projects 2015FY310100(MOST),DD20160120-04(CGS)of China in 2015-2018.
文摘The non-marine Cretaceous-Paleogene boundary(KPgB)in Jiayin of Heilongjiang was first defined and reported in China by the authors research team in 2011.Thereafter the continuous research on the KPgB and its related Late Cretaceous biota in Jiayin has been made by the authors in 2012-2020.The achievements of the research are mainly reflected as follows:(1)a new drilling borehole with 60 m in depth carried out in the Xiaoheyan of Jiayin in 2016,supplemented new palynological evidence for the KPgB definition in 2011;(2)some radiometric dating newly made on the strata related to the KPgB in Jiayin and its neighboring Russian area,provided the supplemental evidence for the KPgB definition in Jiayin;(3)many new fossils found by the authors,represented by the angiosperms Dalembia and Nelumbo,refresh understanding the Late Cretaceous environment of Jiayin;and(4)the TEM method is applied in the study of pollen exine ultrastructure of Pseudointegricorpus,Wodehouseia,and Aquilapollenites,promoting the late Maastrichtian ecological study in Jiayin,related to the KPgB.
文摘Background:This study was carried out to clarify the etiology and clinicopathological features of hepatocellular carcinomas (HCCs) arising in patients without chronic viral infection or alcohol abuse. Methods:HCC patients who underwent resection were divided into three groups:a non-B non-C (NBNC) group (n = 13), who were seronegative for hepatitis B surface antigen (HBs Ag) and anti-hepatitis C antibody (HCV Ab), excluding a history of alcohol abuse; a B group (n = 25), who were seropositive for HBs Ag only; and a C group (n = 116), who were seropositive for HCV Ab only. We analyzed the features of tumor-and host-related factors and the outcome of the NBNC group. Results:Hepatic inflammation and fibrosis were less severe in the NBNC group than in the other groups. There were no significant differences in tumor-related factors, except for higher serum levels of α-fetoprotein in the NBNC group. Recurrence rates and disease-free survivals were comparable among the three groups. The NBNC group comprised a greater population with one or two recurrent hepatic lesions (P < 0.05), and indocyanine green retention rates and fibrosis scores were preserved after the initial hepatectomy. The NBNC group had higher resection rates for intrahepatic recurrences (75.0%) than the other groups (21.1%and 22.2%in groups B and C, respectively; P < 0.05 and P < 0.05). The survival rate after the initial hepatectomy or detection of the recurrent lesions was significantly better in the NBNC group (both 100%at 5 years) than those in groups B and C (P < 0.05). Conclusions:NBNC patients maintained good liver function following the initial hepatectomy, and tended to have one or two recurrent lesions. These biological advantages provided NBNC patients more opportunities for repeat resection of intrahepatic recurrences, which may lead to a favorable outcome.
