A 63-year-old man with chronic lymphocytic leukaemia developed pyodermagan grenosum following minortrauma to the leg. He required intensive inpatient management with a multitude of treatmentsincludinglarvaltherapy,sur...A 63-year-old man with chronic lymphocytic leukaemia developed pyodermagan grenosum following minortrauma to the leg. He required intensive inpatient management with a multitude of treatmentsincludinglarvaltherapy,surgicaldebridement,ciclosporin, methotrexate, thalidomide, pulsed intravenous methyl prednisolone and high-dose intravenous immunoglobulin, clofazamine and high dose oral corticosteroids, none of which were helpful. Treatment complications included steroid-induced diabetes, Cushing’ s syndrome and perforated peptic ulcer. The pyoderma remained refractory to treatment and continued to extend until he received intravenous infliximab 5 mg/kg at weeks 0, 2 and 6.展开更多
文摘A 63-year-old man with chronic lymphocytic leukaemia developed pyodermagan grenosum following minortrauma to the leg. He required intensive inpatient management with a multitude of treatmentsincludinglarvaltherapy,surgicaldebridement,ciclosporin, methotrexate, thalidomide, pulsed intravenous methyl prednisolone and high-dose intravenous immunoglobulin, clofazamine and high dose oral corticosteroids, none of which were helpful. Treatment complications included steroid-induced diabetes, Cushing’ s syndrome and perforated peptic ulcer. The pyoderma remained refractory to treatment and continued to extend until he received intravenous infliximab 5 mg/kg at weeks 0, 2 and 6.
