Aim:The aim was to evaluate the efficacy of platelet-rich plasma(PRP)in the treatment of chronic nonhealing ulcers.Methods:A nonrandomized,uncontrolled study was performed on 24 patients with 33 nonhealing ulcers of v...Aim:The aim was to evaluate the efficacy of platelet-rich plasma(PRP)in the treatment of chronic nonhealing ulcers.Methods:A nonrandomized,uncontrolled study was performed on 24 patients with 33 nonhealing ulcers of various etiologies.All patients were treated with PRP at weekly intervals for a maximum of 6 treatments.At the end of the 6-week period,reduction in size of the ulcers(area and volume)was assessed.Results:The mean age of the patients was 42.5 years(standard deviation[SD]12.48).Of 33 ulcers,there were 19 venous ulcers,7 traumatic ulcers,2 ulcers secondary to pyoderma gangrenosum,2 diabetic ulcers,2 trophic ulcers,and 1 vasculitic ulcer.The mean duration of healing of the ulcers was 5.6 weeks(SD 3.23).The mean percentage of reduction in area and volume of the ulcers was 91.7%(SD 18.4%)and 95%(SD 14%),respectively.About 100%resolution in the area was seen in 25(76%)of the ulcers and 100%reduction in volume was seen in 24(73%)of the ulcers at the end of the 6th treatment.Conclusion:Conventional therapies do not provide satisfactory healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors(GFs)(platelet-derived GF,epidermal GF,vascular endothelial GF,etc.)which are essential for the healing process.PRP is a safe,affordable,biocompatible,and simple office-based procedure for the treatment of nonhealing ulcers.展开更多
文摘Aim:The aim was to evaluate the efficacy of platelet-rich plasma(PRP)in the treatment of chronic nonhealing ulcers.Methods:A nonrandomized,uncontrolled study was performed on 24 patients with 33 nonhealing ulcers of various etiologies.All patients were treated with PRP at weekly intervals for a maximum of 6 treatments.At the end of the 6-week period,reduction in size of the ulcers(area and volume)was assessed.Results:The mean age of the patients was 42.5 years(standard deviation[SD]12.48).Of 33 ulcers,there were 19 venous ulcers,7 traumatic ulcers,2 ulcers secondary to pyoderma gangrenosum,2 diabetic ulcers,2 trophic ulcers,and 1 vasculitic ulcer.The mean duration of healing of the ulcers was 5.6 weeks(SD 3.23).The mean percentage of reduction in area and volume of the ulcers was 91.7%(SD 18.4%)and 95%(SD 14%),respectively.About 100%resolution in the area was seen in 25(76%)of the ulcers and 100%reduction in volume was seen in 24(73%)of the ulcers at the end of the 6th treatment.Conclusion:Conventional therapies do not provide satisfactory healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors(GFs)(platelet-derived GF,epidermal GF,vascular endothelial GF,etc.)which are essential for the healing process.PRP is a safe,affordable,biocompatible,and simple office-based procedure for the treatment of nonhealing ulcers.
