50 patients with chronic renal failure undergoing hemodia- lysis with or without porphyria cutanea tarda (PCT) like skin changes were investigated. The total porphyrin amount in erythrocytes, plasma and dialysate and ...50 patients with chronic renal failure undergoing hemodia- lysis with or without porphyria cutanea tarda (PCT) like skin changes were investigated. The total porphyrin amount in erythrocytes, plasma and dialysate and the distribution of porphyrin metabolites in plasma and dialysate were measured. In plasma, the group of patients with skin changes (referred as PCU =porphyria cutanea uremica) showed significantly increased uroporphyrin levels as compared to the non-symptomatic group. In addition, significant differences concerning the ratio uro/coproporphyrin in plasma were shown: non-symptomatic patients with 0.87, as opposed to the PCU group with 3.7. Considerable differences between the level of vitamin ingestion were identified between the groups. Patients with PCU took distinctly less vitamins C, E and B than patients without symptoms.展开更多
Patientswithsystemicsclerosis(SSc)developoftenacralulcers which are resistant to therapy and may result in gangrene and amputation. We investigated the effect s of iloprost infusion on the acral ulcers and necrosis in...Patientswithsystemicsclerosis(SSc)developoftenacralulcers which are resistant to therapy and may result in gangrene and amputation. We investigated the effect s of iloprost infusion on the acral ulcers and necrosis in patients with five pa tients with SSc and one with mixed connective tissue disease who had been previo usly treated with various modalities without improvement. All patients had Rayna ud phenomenon, acral ulcers and necrosis. Iloprost 25 μg per day was administer ed intravenously daily over six hours for ten consecutive days. Eight weeks late r all patients were treated with a second iloprost therapy cycle for five days. Two patients with severe ulceration received a third cycle until remission occur red. In all cases acral ulcers hea led com pletely and no patient relapsed durin g an observation period of 6 months.展开更多
文摘50 patients with chronic renal failure undergoing hemodia- lysis with or without porphyria cutanea tarda (PCT) like skin changes were investigated. The total porphyrin amount in erythrocytes, plasma and dialysate and the distribution of porphyrin metabolites in plasma and dialysate were measured. In plasma, the group of patients with skin changes (referred as PCU =porphyria cutanea uremica) showed significantly increased uroporphyrin levels as compared to the non-symptomatic group. In addition, significant differences concerning the ratio uro/coproporphyrin in plasma were shown: non-symptomatic patients with 0.87, as opposed to the PCU group with 3.7. Considerable differences between the level of vitamin ingestion were identified between the groups. Patients with PCU took distinctly less vitamins C, E and B than patients without symptoms.
文摘Patientswithsystemicsclerosis(SSc)developoftenacralulcers which are resistant to therapy and may result in gangrene and amputation. We investigated the effect s of iloprost infusion on the acral ulcers and necrosis in patients with five pa tients with SSc and one with mixed connective tissue disease who had been previo usly treated with various modalities without improvement. All patients had Rayna ud phenomenon, acral ulcers and necrosis. Iloprost 25 μg per day was administer ed intravenously daily over six hours for ten consecutive days. Eight weeks late r all patients were treated with a second iloprost therapy cycle for five days. Two patients with severe ulceration received a third cycle until remission occur red. In all cases acral ulcers hea led com pletely and no patient relapsed durin g an observation period of 6 months.
