The biocompatibility of biphasicα,β-tricalcium phosphate ceramics,obtained by annealing a compact preform based onβ-tricalcium phosphate powder,was studied in vitro.It was found that within 10–30 days the adhesion...The biocompatibility of biphasicα,β-tricalcium phosphate ceramics,obtained by annealing a compact preform based onβ-tricalcium phosphate powder,was studied in vitro.It was found that within 10–30 days the adhesion of primary dental pulp stem cells located on the surface of biphasicα,β-tricalcium phosphate ceramics is suppressed.Decrease of the cell number on the surface of biphasicα,β-tricalcium phosphate ceramics,most likely,can be associated with both the pH level(acidic)as a result of hydrolysis of the more soluble phase ofα-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.展开更多
A technique for colloidal forming of Ca2P2O7 macroporous bioceramics,based on low-pressure injection molding(LPIM)of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3Dpr...A technique for colloidal forming of Ca2P2O7 macroporous bioceramics,based on low-pressure injection molding(LPIM)of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3Dprinting,was proposed.Chemical reaction between the solid phases of the water containing slip-Ca2P2O7 and Ca(Н2PO4)2,resulting in brushite(CaHPO4·2H2O)formation,led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out.Macroporous ceramics of Kelvin structure(70%macropores with the sizes from 2 up to 4 mm),based on a pre-defined composition with 10 wt%Ca(PO3)2 and sintered in liquid-phase regime,demonstrated a compressive strength of 1.4±0.1 MPa at a density of 22±2%.In vitro tests on bioactivity in SBF solution,as well as on resorption of the ceramics in model solution of citric acid,were carried out.展开更多
文摘The biocompatibility of biphasicα,β-tricalcium phosphate ceramics,obtained by annealing a compact preform based onβ-tricalcium phosphate powder,was studied in vitro.It was found that within 10–30 days the adhesion of primary dental pulp stem cells located on the surface of biphasicα,β-tricalcium phosphate ceramics is suppressed.Decrease of the cell number on the surface of biphasicα,β-tricalcium phosphate ceramics,most likely,can be associated with both the pH level(acidic)as a result of hydrolysis of the more soluble phase ofα-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.
基金supported by the RFBR(grants No.18-33-00789 mol_a,18-08-01473,19-03-00940)。
文摘A technique for colloidal forming of Ca2P2O7 macroporous bioceramics,based on low-pressure injection molding(LPIM)of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3Dprinting,was proposed.Chemical reaction between the solid phases of the water containing slip-Ca2P2O7 and Ca(Н2PO4)2,resulting in brushite(CaHPO4·2H2O)formation,led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out.Macroporous ceramics of Kelvin structure(70%macropores with the sizes from 2 up to 4 mm),based on a pre-defined composition with 10 wt%Ca(PO3)2 and sintered in liquid-phase regime,demonstrated a compressive strength of 1.4±0.1 MPa at a density of 22±2%.In vitro tests on bioactivity in SBF solution,as well as on resorption of the ceramics in model solution of citric acid,were carried out.
