目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查...目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查对象的一般资料、血浆LDL-C水平等信息。采用logistic回归分析LDL-C与肾功能轻度下降的关系。结果1959例高血压患者年龄为(69.2±7.0)岁,肾功能轻度下降患者1231例(62.8%)。调整性别等相关因素后,高血压患者LDL-C与肾功能轻度下降呈正相关,LDL-C每增加1 mmol/L,肾功能轻度下降发生的风险增加57%(OR=1.570,95%CI:1.359~1.813)。将LDL-C三等分,与最低三分位数(T1,<2.2 mmol/L)的患者比较,中三分位数(T2,2.2~<2.9 mmol/L)和最高三分位数(T3,≥2.9 mmol/L)的患者肾功能轻度下降的风险分别增加1.028倍(OR=2.028,95%CI:1.578~2.605)和2.721倍(OR=3.721,95%CI:2.814~4.920)。舒张压升高与LDL-C水平升高对增加肾功能轻度下降风险具有协同作用(舒张压<90 mm Hg vs.≥90 mm Hg,1 mm Hg=0.133 kPa,P_(交互)=0.006)。结论高血压患者LDL-C与肾功能轻度下降呈正相关关系,尤其在舒张压升高的人群中。提示控制高血压患者LDL-C和血压水平可以降低肾功能轻度下降的风险,减轻肾脏靶器官的早期损害。展开更多
Background Although the first leading cause of death in China was malignant neoplasms （mortality, 374.1 per 100 000 person-years）, the full impact of primary brain tumors （PBT） on the healthcare system is not comp...Background Although the first leading cause of death in China was malignant neoplasms （mortality, 374.1 per 100 000 person-years）, the full impact of primary brain tumors （PBT） on the healthcare system is not completely described because there are a few well documented reports about the epidemiologic features of brain tumors. This study aimed to report a comprehensive assessment on the prevalence of PBT. Methods A multicenter cross-sectional study on brain tumor （MCSBT） in China was initiated in five regional centers： Daqing （northeast）, Puyang （north of China）, Shiyan （center of China）, Ma＇anshan （center of China） and Shanghai （southeast）. Prevalence rate was calculated by counting the number of people living with a PBT between October 1,2005 and September 30, 2006 and dividing by the total population of the five communities at January 1, 2006. Estimates of prevalence were expressed as percentages and grouped according to gender and to age in fifteen-year categories. Within these strata, the rates were estimated with 95% confidence intervals （C/） using the accurate calculation of CI for Poisson distribution. A chi-square test was used to compare the various frequencies with a 〈0.05. Age-standardized prevalence with the direct method was calculated with the ten-year age-specific prevalence and the age distribution of population prospects： the 2008 revision. Results We estimated that the overall prevalence of PBT was 24.56 per 100 000 （95% CI, 14.85 to 34.27）, and the overall prevalence of PBT in female population （30.57 per 100 000 and its 95% Cl ranged from 19.73 to 41.41） was higher than that in male population （18.84 per 100 000 and its 95% Cl ranged from 10.33 to 27.35）. However, the discrepancy between genders was not statistically significant because the 95% Cl overlapped. Of 272 cases of newly diagnosed PBT, the proportion of histological subtypes by age groups, gender was statistically different （X2=52.6510, P 〈0.0001）. More than half of all reported tumors （52.57%） were either gliomas or meningiomas. For the youngest （aged from 0-19） strata of the population, glioma appeared to occur more than other subtypes, accounting for 55.56% of all of cases. The majority of brain tumors presented in those aged from 20 to 59 years was pituitary adenomas （45.12%） and gliomas （31.10%）. Opposed to brain tumors in adults and teenage, gliomas only accounted for 22.22%. Meanwhile, the median ages at diagnosis of the patients with PBT were similar between males and females except for pituitary adenomas （male： 59 years old; female： 45 years old）. Conclusions Age standardized prevalence of PBT is 22.52 per 100 000 （95% CI, 13.22 to 31.82） for all populations, 17.64 per 100 000 （95% CI, 9.41 to 25.87） for men, and 27.94 per 100 000 （95% Cl, 17.58 to 38.30） for women. Age standardization to China＇s 2010 population yielded an estimated population of 304 954 cases with PBT. Our prevalence estimates provide a conservative basis on which to plan health care services and to develop programmatic strategies for surviving. Inthe future, it would be helpful to have long-term observed survival rates that would make the assumptions and the resulting imprecision in the current estimates unnecessary.展开更多
文摘目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查对象的一般资料、血浆LDL-C水平等信息。采用logistic回归分析LDL-C与肾功能轻度下降的关系。结果1959例高血压患者年龄为(69.2±7.0)岁,肾功能轻度下降患者1231例(62.8%)。调整性别等相关因素后,高血压患者LDL-C与肾功能轻度下降呈正相关,LDL-C每增加1 mmol/L,肾功能轻度下降发生的风险增加57%(OR=1.570,95%CI:1.359~1.813)。将LDL-C三等分,与最低三分位数(T1,<2.2 mmol/L)的患者比较,中三分位数(T2,2.2~<2.9 mmol/L)和最高三分位数(T3,≥2.9 mmol/L)的患者肾功能轻度下降的风险分别增加1.028倍(OR=2.028,95%CI:1.578~2.605)和2.721倍(OR=3.721,95%CI:2.814~4.920)。舒张压升高与LDL-C水平升高对增加肾功能轻度下降风险具有协同作用(舒张压<90 mm Hg vs.≥90 mm Hg,1 mm Hg=0.133 kPa,P_(交互)=0.006)。结论高血压患者LDL-C与肾功能轻度下降呈正相关关系,尤其在舒张压升高的人群中。提示控制高血压患者LDL-C和血压水平可以降低肾功能轻度下降的风险,减轻肾脏靶器官的早期损害。
文摘Background Although the first leading cause of death in China was malignant neoplasms （mortality, 374.1 per 100 000 person-years）, the full impact of primary brain tumors （PBT） on the healthcare system is not completely described because there are a few well documented reports about the epidemiologic features of brain tumors. This study aimed to report a comprehensive assessment on the prevalence of PBT. Methods A multicenter cross-sectional study on brain tumor （MCSBT） in China was initiated in five regional centers： Daqing （northeast）, Puyang （north of China）, Shiyan （center of China）, Ma＇anshan （center of China） and Shanghai （southeast）. Prevalence rate was calculated by counting the number of people living with a PBT between October 1,2005 and September 30, 2006 and dividing by the total population of the five communities at January 1, 2006. Estimates of prevalence were expressed as percentages and grouped according to gender and to age in fifteen-year categories. Within these strata, the rates were estimated with 95% confidence intervals （C/） using the accurate calculation of CI for Poisson distribution. A chi-square test was used to compare the various frequencies with a 〈0.05. Age-standardized prevalence with the direct method was calculated with the ten-year age-specific prevalence and the age distribution of population prospects： the 2008 revision. Results We estimated that the overall prevalence of PBT was 24.56 per 100 000 （95% CI, 14.85 to 34.27）, and the overall prevalence of PBT in female population （30.57 per 100 000 and its 95% Cl ranged from 19.73 to 41.41） was higher than that in male population （18.84 per 100 000 and its 95% Cl ranged from 10.33 to 27.35）. However, the discrepancy between genders was not statistically significant because the 95% Cl overlapped. Of 272 cases of newly diagnosed PBT, the proportion of histological subtypes by age groups, gender was statistically different （X2=52.6510, P 〈0.0001）. More than half of all reported tumors （52.57%） were either gliomas or meningiomas. For the youngest （aged from 0-19） strata of the population, glioma appeared to occur more than other subtypes, accounting for 55.56% of all of cases. The majority of brain tumors presented in those aged from 20 to 59 years was pituitary adenomas （45.12%） and gliomas （31.10%）. Opposed to brain tumors in adults and teenage, gliomas only accounted for 22.22%. Meanwhile, the median ages at diagnosis of the patients with PBT were similar between males and females except for pituitary adenomas （male： 59 years old; female： 45 years old）. Conclusions Age standardized prevalence of PBT is 22.52 per 100 000 （95% CI, 13.22 to 31.82） for all populations, 17.64 per 100 000 （95% CI, 9.41 to 25.87） for men, and 27.94 per 100 000 （95% Cl, 17.58 to 38.30） for women. Age standardization to China＇s 2010 population yielded an estimated population of 304 954 cases with PBT. Our prevalence estimates provide a conservative basis on which to plan health care services and to develop programmatic strategies for surviving. Inthe future, it would be helpful to have long-term observed survival rates that would make the assumptions and the resulting imprecision in the current estimates unnecessary.
