金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出...金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出。研究介绍了一种用于金属磁微量能计信号读出的两级超导量子干涉器电路。初级放大器的设计采用了二阶梯度计构型,测试结果显示该设计方案有效的抑制了环境噪声的干扰。在液氦温度下,两级放大电路在磁通锁定环模式下实现了27400 V/A的跨阻增益,白噪声水平达到11.5 pA/Hz^(1/2)。展开更多
Background Atrial tachycardia(AT)with cycle length(CL)alternans is uncommon and conventional mapping of this AT remains challenging. We used an ultrahigh density mapping system to rapidly map complicated circuits with...Background Atrial tachycardia(AT)with cycle length(CL)alternans is uncommon and conventional mapping of this AT remains challenging. We used an ultrahigh density mapping system to rapidly map complicated circuits with sufficient spatial resolution and electrogram quality to elucidate the precise mechanism of this special ATs. Methods Of 210 consecutive patients with clinical ATs who underwent catheter ablation with the ultrahigh density mapping system,4 patients(1.9%)with CL alternans were identified. The AT alternating cycles mapped by the Rhythmia mapping system for long CL were 317±51(range 245-355)ms and for short CL were 282±51(range 235-333)ms. Both long and short cycles followed in 1∶1 sequence in all 4 patients(longshort-long-short). Results By comparing the separate maps with long and short CL,we classified ATs with CL alternans into 2 types. In type 1,CL alternans resulted from an intermittent 2∶1 conduction block through the slow conduction channel in the small circuit. In type 2,CL alternans caused by the alternated conduction velocity passing through the conduction gap were manifested. Ablation at the fractionated potentials contributes to the termination of AT in 3 of the 4 patients. Conclusions Ultrahigh density mapping system can accurately identify the mechanism of complex ATs with alternating CL. The CL alternans may be related to the intermittent conduction block within the channel of the small circuitor different conduction velocity through the identical channel. Fractionated electrogram recorded in the common isthmus or some"conduction gaps"may be a reasonable approach to terminate these ATs.展开更多
文摘金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出。研究介绍了一种用于金属磁微量能计信号读出的两级超导量子干涉器电路。初级放大器的设计采用了二阶梯度计构型,测试结果显示该设计方案有效的抑制了环境噪声的干扰。在液氦温度下,两级放大电路在磁通锁定环模式下实现了27400 V/A的跨阻增益,白噪声水平达到11.5 pA/Hz^(1/2)。
基金supported by the Key Research and Development Projects of Guangdong Province(No. 2019B020230004)the National Key Research and Development Projects (No. 2018YFC1312501/2018YFC1312502)the National Natural Science Foundation (No. 81870254)
文摘Background Atrial tachycardia(AT)with cycle length(CL)alternans is uncommon and conventional mapping of this AT remains challenging. We used an ultrahigh density mapping system to rapidly map complicated circuits with sufficient spatial resolution and electrogram quality to elucidate the precise mechanism of this special ATs. Methods Of 210 consecutive patients with clinical ATs who underwent catheter ablation with the ultrahigh density mapping system,4 patients(1.9%)with CL alternans were identified. The AT alternating cycles mapped by the Rhythmia mapping system for long CL were 317±51(range 245-355)ms and for short CL were 282±51(range 235-333)ms. Both long and short cycles followed in 1∶1 sequence in all 4 patients(longshort-long-short). Results By comparing the separate maps with long and short CL,we classified ATs with CL alternans into 2 types. In type 1,CL alternans resulted from an intermittent 2∶1 conduction block through the slow conduction channel in the small circuit. In type 2,CL alternans caused by the alternated conduction velocity passing through the conduction gap were manifested. Ablation at the fractionated potentials contributes to the termination of AT in 3 of the 4 patients. Conclusions Ultrahigh density mapping system can accurately identify the mechanism of complex ATs with alternating CL. The CL alternans may be related to the intermittent conduction block within the channel of the small circuitor different conduction velocity through the identical channel. Fractionated electrogram recorded in the common isthmus or some"conduction gaps"may be a reasonable approach to terminate these ATs.
