目的:探讨基于多学科糖尿病护理团队(multidisciplinar y diabetes care team,MDCT)的“互联网+”远程管理模式对妊娠糖尿病(gestational diabetes mel litus,GDM)患者治疗依从性、血糖控制情况、生活质量及妊娠结局的影响。方法:选取2...目的:探讨基于多学科糖尿病护理团队(multidisciplinar y diabetes care team,MDCT)的“互联网+”远程管理模式对妊娠糖尿病(gestational diabetes mel litus,GDM)患者治疗依从性、血糖控制情况、生活质量及妊娠结局的影响。方法:选取2019年1月至2020年12月就诊的140例GDM患者为研究对象,随机分成对照组和研究组,每组70例。构建基于MDCT的“互联网+”远程管理模式。对照组采用MDCT管理模式进行管理,研究组在对照组MDCT管理方案的基础上采用基于“互联网+”的个体化远程管理。干预前及分娩前1周,应用糖尿病治疗依从性量表评估两组患者的治疗依从性,监测两组患者的血糖水平并计算血糖达标率,采用36项健康调查简表(Short-Form 36-item,SF-36)评估两组患者的生活质量,随后比较两组上述指标干预前后的变化情况及组间差异。妊娠结束后,比较两组的妊娠结局以及患者对干预方法的满意度。结果:截至研究结束时两组各失访7例。两组患者干预后药物、饮食、运动、自我监测、定期复查5个维度的治疗依从性得分及总得分均显著高于干预前(P<0.05或P<0.001),且研究组的改善程度均显著高于对照组(P<0.05或P<0.001);研究组治疗依从性较好率为90.48%,显著高于对照组(42.86%),差异有统计学意义(P<0.001)。两组患者干预后的空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 h postprandial blood glucose,2hPBG)以及糖化血红蛋白(glycosylated hemoglobin,HbA1c)水平均显著改善(均P<0.001),且研究组的改善程度均显著优于对照组(P<0.05或P<0.001);对照组干预后血糖达标率为9.52%,显著高于对照组,差异有统计学意义(P=0.036)。对照组干预后在总体健康、精神健康方面的评分均显著降低(均P<0.05),但研究组的上述评分均较干预前显著升高且高于对照组(均P<0.05);两组干预后活力、社会功能方面的评分均显著降低(均P<0.001),但研究组的降低程度均显著低于对照组(P<0.05或P<0.001)。研究组患者羊水过多、新生儿低血糖、胎儿生长受限发生率均显著低于对照组(均P<0.05);但胎膜早破、早产、巨大儿及新生儿呼吸窘迫发生率与对照组比较差异无统计学意义(P>0.05)。针对所接受的干预方法,研究组患者满意度显著高于对照组(P<0.05)。结论:对GDM患者采用基于MDCT的“互联网+”远程管理模式进行管理,可提高患者的治疗依从性、改善血糖控制水平及生活质量,同时可降低母婴并发症发生率,效果满意、值得推广。展开更多
The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps t...The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps taii and C.memorabilis caused significant(P<0.01)decreases in mice blood sugar levels.Polysaccharides from Ganoderma lucidum and C.militaris fruit bodies both exhibited weak hypoglycemic effects at significance levels of P<0.01 and P<0.05 for high and low doses,respectively.Polysaccharide extracted from mycelium of a Phellinus sp.was significantly(P<0.05)hypoglycemic at higher dose levels but lower doses had no effect.展开更多
The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clea...The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clearance and delayed-type hypersensitivity testing(DTH),and by determining thymic and splenic indices.Polysaccharide,adenosine and mannitol levels in C.taii were 36.20 mg/g,0.27 mg/g and 80.20 mg/g,respectively.Aqueous C.taii extracts partially alleviated the suppressive effects on the thymic and splenic indices caused by cyclophosphamide,and increased nonspecific immunity and cellular immune functions.Toxicity tests revealed that the LD50 for aqueous C.taii extract on oral administration was >69.42 g/kg.展开更多
基金Sponsored by the Foundation of Guangdong Province(No.2005B333701016,2006B20201038)
文摘The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps taii and C.memorabilis caused significant(P<0.01)decreases in mice blood sugar levels.Polysaccharides from Ganoderma lucidum and C.militaris fruit bodies both exhibited weak hypoglycemic effects at significance levels of P<0.01 and P<0.05 for high and low doses,respectively.Polysaccharide extracted from mycelium of a Phellinus sp.was significantly(P<0.05)hypoglycemic at higher dose levels but lower doses had no effect.
基金the Foundation of Guangdong Province(No.2005B33701016 and No.2006B20201038)
文摘The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clearance and delayed-type hypersensitivity testing(DTH),and by determining thymic and splenic indices.Polysaccharide,adenosine and mannitol levels in C.taii were 36.20 mg/g,0.27 mg/g and 80.20 mg/g,respectively.Aqueous C.taii extracts partially alleviated the suppressive effects on the thymic and splenic indices caused by cyclophosphamide,and increased nonspecific immunity and cellular immune functions.Toxicity tests revealed that the LD50 for aqueous C.taii extract on oral administration was >69.42 g/kg.
