We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）,...We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEl-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently com- pared with PEI-25kDa.展开更多
The regioselective allylic alkylation of 1,2-dihydroquinolines and Morita-Baylis-Hillman（MBH） adducts has been developed. By surveying various reaction parameters, we summarized the effects of temperatures, relative...The regioselective allylic alkylation of 1,2-dihydroquinolines and Morita-Baylis-Hillman（MBH） adducts has been developed. By surveying various reaction parameters, we summarized the effects of temperatures, relative reactant doses, catalysts, solvents and N-protected groups on the regioselectivity of this transformation. This method provides a facile protocol for the preparation of allylic a-substituted dihydroquinolines.展开更多
文摘We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEl-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently com- pared with PEI-25kDa.
文摘The regioselective allylic alkylation of 1,2-dihydroquinolines and Morita-Baylis-Hillman（MBH） adducts has been developed. By surveying various reaction parameters, we summarized the effects of temperatures, relative reactant doses, catalysts, solvents and N-protected groups on the regioselectivity of this transformation. This method provides a facile protocol for the preparation of allylic a-substituted dihydroquinolines.
