BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract hemorrhage.Moreover,we aimed to evaluate th...BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract hemorrhage.Moreover,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula resection.AIM To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with bleeding.METHODS The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of diverticula.RESULTS(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 years.The incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was<1,suggesting that the blood loss of most MD patients was less than 20%–30%,and only a few patients had a blood loss of>30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before surgery.DBE endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal ulcer was the main cause of MD and bleeding;and(6)Laparoscopic dissection of diverticulae was performed in 76 patients,The patients who underwent postoperative follow-up did not experience any further bleeding.Additionally,follow-up examination of the 8 cases who had declined surgery revealed that 3 of them experienced a recurrence of digestive tract bleeding.These findings indicate that laparoscopic diverticula resection in MD patients complicated by bleeding had a favorable prognosis.CONCLUSION Bleeding associated with MD was predominantly observed in male adolescents,particularly at a young age.DBE was a highly precise examination method in MD diagnosis.Laparoscopic diverticula resection effectively prevented MD bleeding and had a good prognosis.展开更多
Diabetic wounds significantly affect patient quality of life.Microneedles are a promising treatment to accelerate wound healing owing to their high drug-loading capacity and efficient drug delivery;however,few studies...Diabetic wounds significantly affect patient quality of life.Microneedles are a promising treatment to accelerate wound healing owing to their high drug-loading capacity and efficient drug delivery;however,few studies to date have comprehensively reviewed microneedles for diabetic wound healing.This up-to-date review summarizes the research progress in microneedles for diabetic wound healing,including manufacturing materials and techniques,structures,designs,release mechanisms,delivery substances,and their specific effects.This study showed that most microneedles designed for diabetic wounds are made of synthetic polymers and/or natural materials using polydimethylsiloxane micromolding.The geometric structure and design directly influence penetration ability and drug delivery capacity.Microneedles can deliver antibiotics,hypoglycemic agents,traditional Chinese medicines,metal ions,growth factors,exosomes,stem cells,and microorganisms,thus promoting diabetic wound healing through diverse mechanisms,such as antibacterial,anti-inflammatory,antioxidant,hypoglycemic,and angiogenic activities,at different stages of the healing process.In conclusion,microneedles are promising drug delivery systems for the treatment of diabetic wounds.展开更多
This experiment was conducted to investigate the effects of heat stress(HS) on the feed intake, milk production and composition and metabolic alterations in the mammary gland of dairy cows. Twenty Holstein cows were r...This experiment was conducted to investigate the effects of heat stress(HS) on the feed intake, milk production and composition and metabolic alterations in the mammary gland of dairy cows. Twenty Holstein cows were randomly assigned to one of two treatments according to a completely randomized design. Half of the cows were allocated to the HS group in August(summer season), and the other half were assigned to the HS-free group in November(autumn season). HS reduced(P<0.01) dry matter intake(DMI), milk yield, milk protein and milk urea nitrogen(MUN) of cows compared with HSfree control, but increased(P<0.01) milk somatic cell counts(SCC). We determined the HS-induced metabolic alterations and the relevant mechanisms in dairy cows using liquid chromatography mass spectrometry combined with multivariate analyses. Thirty-four metabolites were identified as potential biomarkers for the diagnosis of HS in dairy cows. Ten of these metabolites, glucose, lactate, pyruvate, lactose, β-hydroxybutyrate, citric acid, α-ketoglutarate, urea, creatine, and orotic acid, had high sensitivity and specificity for HS diagnoses, and seven metabolites were also identified as potential biomarkers of HS in plasma, milk, and liver. These substances are involved in glycolysis, lactose, ketone, tricarboxylic acid(TCA), amino acid and nucleotide metabolism, indicating that HS mainly affects lactose, energy and nucleotide metabolism in the mammary gland of lactating dairy cows. This study suggested that HS might affect milk production and composition by affecting the feed intake and substance metabolisms in the mammary gland tissue of lactating dairy cows.展开更多
This paper explains trajectory-based data forwarding schemes for multihop data delivery in vehicular networks where the trajectory is the GPS navigation path for driving in a road network. Nowadays, GPS-based navigati...This paper explains trajectory-based data forwarding schemes for multihop data delivery in vehicular networks where the trajectory is the GPS navigation path for driving in a road network. Nowadays, GPS-based navigation is popular with drivers either for efficient driv- ing in unfamiliar road networks or for a better route, even in familiar road networks with heavy traffic. In this paper, we describe how to take advantage of vehicle trajectories in order to design data-forwarding schemes for information exchange in vehicular networks. The design of data-forwarding schemes takes into account not only the macro-scoped mobility of vehicular traffic statistics in road net- works, but also the micro-scoped mobility of individual vehicle trajectories. This paper addresses the importance of vehicle trajectory in the design of multihop vehicle-to-infrastructure, infrastructure-to-vehicle, and vehicle-to-vehicle data forwarding schemes. First, we explain the modeling of packet delivery delay and vehicle travel delay in both a road segment and an end-to-end path in a road net- work. Second, we describe a state-of-the-art data forwarding scheme using vehicular traffic statistics for the estimation of the end-to- end delivery delay as a forwarding metric. Last, we describe two data forwarding schemes based on both vehicle trajectory and vehicu- lar traffic statistics in a privacy-preserving manner.展开更多
Mono- and dual-branched molecules, { 4-[2-（4-benzothiazol-2-yl-phenyl）-vinyl]-phenyl}-（4-methoxy-phenyl）-phenyl- amine （BS1） and bis-{4-[2- （4-benzothiazol-2-yl-phenyl）-vinyI]-phenyl}-（4-methoxy-phenyI）-phen...Mono- and dual-branched molecules, { 4-[2-（4-benzothiazol-2-yl-phenyl）-vinyl]-phenyl}-（4-methoxy-phenyl）-phenyl- amine （BS1） and bis-{4-[2- （4-benzothiazol-2-yl-phenyl）-vinyI]-phenyl}-（4-methoxy-phenyI）-phenyl-amine （BS2）, are investigated with one- and two-photon static spectroscopy, and the femtosecond fluorescence up-conversion technique. The molecules show branch-based fluorescence emission at low quantum yield. U1trafast non-radiative decay on a picosecond time scale is found and is attributed to intramolecular charge-transfer bridged by the central triphenylamine. The two-photon absorption cross-sections of BS1 and BS2 are 19.1 and 19.4 GM, respectively.展开更多
基金Supported by the Ten Thousand Doctor Plan in Yunnan Province,No.YNWR-MY-2018-020Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province,No.2021LCZXXF-XH07,No.2021LCZXXF-XH15,and No.2022LCZXKF-XH17Yunnan Provincial Key Laboratory of Clinical Virology,No.202205AG070053-07.
文摘BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract hemorrhage.Moreover,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula resection.AIM To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with bleeding.METHODS The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of diverticula.RESULTS(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 years.The incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was<1,suggesting that the blood loss of most MD patients was less than 20%–30%,and only a few patients had a blood loss of>30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before surgery.DBE endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal ulcer was the main cause of MD and bleeding;and(6)Laparoscopic dissection of diverticulae was performed in 76 patients,The patients who underwent postoperative follow-up did not experience any further bleeding.Additionally,follow-up examination of the 8 cases who had declined surgery revealed that 3 of them experienced a recurrence of digestive tract bleeding.These findings indicate that laparoscopic diverticula resection in MD patients complicated by bleeding had a favorable prognosis.CONCLUSION Bleeding associated with MD was predominantly observed in male adolescents,particularly at a young age.DBE was a highly precise examination method in MD diagnosis.Laparoscopic diverticula resection effectively prevented MD bleeding and had a good prognosis.
基金the Joint Logistic Support Force Grant for Outstanding Young Top Scholars(grant no.2022-22).
文摘Diabetic wounds significantly affect patient quality of life.Microneedles are a promising treatment to accelerate wound healing owing to their high drug-loading capacity and efficient drug delivery;however,few studies to date have comprehensively reviewed microneedles for diabetic wound healing.This up-to-date review summarizes the research progress in microneedles for diabetic wound healing,including manufacturing materials and techniques,structures,designs,release mechanisms,delivery substances,and their specific effects.This study showed that most microneedles designed for diabetic wounds are made of synthetic polymers and/or natural materials using polydimethylsiloxane micromolding.The geometric structure and design directly influence penetration ability and drug delivery capacity.Microneedles can deliver antibiotics,hypoglycemic agents,traditional Chinese medicines,metal ions,growth factors,exosomes,stem cells,and microorganisms,thus promoting diabetic wound healing through diverse mechanisms,such as antibacterial,anti-inflammatory,antioxidant,hypoglycemic,and angiogenic activities,at different stages of the healing process.In conclusion,microneedles are promising drug delivery systems for the treatment of diabetic wounds.
基金supported financially by the National Key Research and Development Program of China (2016YFD0500503)the Shanghai Science and Technology Promotion Project for Agriculture (Shanghai Agriculture Science Promotion Project (2019) No. 1-2)
文摘This experiment was conducted to investigate the effects of heat stress(HS) on the feed intake, milk production and composition and metabolic alterations in the mammary gland of dairy cows. Twenty Holstein cows were randomly assigned to one of two treatments according to a completely randomized design. Half of the cows were allocated to the HS group in August(summer season), and the other half were assigned to the HS-free group in November(autumn season). HS reduced(P<0.01) dry matter intake(DMI), milk yield, milk protein and milk urea nitrogen(MUN) of cows compared with HSfree control, but increased(P<0.01) milk somatic cell counts(SCC). We determined the HS-induced metabolic alterations and the relevant mechanisms in dairy cows using liquid chromatography mass spectrometry combined with multivariate analyses. Thirty-four metabolites were identified as potential biomarkers for the diagnosis of HS in dairy cows. Ten of these metabolites, glucose, lactate, pyruvate, lactose, β-hydroxybutyrate, citric acid, α-ketoglutarate, urea, creatine, and orotic acid, had high sensitivity and specificity for HS diagnoses, and seven metabolites were also identified as potential biomarkers of HS in plasma, milk, and liver. These substances are involved in glycolysis, lactose, ketone, tricarboxylic acid(TCA), amino acid and nucleotide metabolism, indicating that HS mainly affects lactose, energy and nucleotide metabolism in the mammary gland of lactating dairy cows. This study suggested that HS might affect milk production and composition by affecting the feed intake and substance metabolisms in the mammary gland tissue of lactating dairy cows.
基金supported by Faculty Research Fund,Sungkyunkwan University,2013 and by DGIST CPS Global Centerpartly supported by Next-Generation Information Computing Development Program through the National Research Foundation of Korea(NRF)+1 种基金funded by the Ministry of Science,ICT & Future Planning(No.2012033347)the ITR & D program of MKE/KEIT(10041244,SmartTV 2.0 Software Platform)
文摘This paper explains trajectory-based data forwarding schemes for multihop data delivery in vehicular networks where the trajectory is the GPS navigation path for driving in a road network. Nowadays, GPS-based navigation is popular with drivers either for efficient driv- ing in unfamiliar road networks or for a better route, even in familiar road networks with heavy traffic. In this paper, we describe how to take advantage of vehicle trajectories in order to design data-forwarding schemes for information exchange in vehicular networks. The design of data-forwarding schemes takes into account not only the macro-scoped mobility of vehicular traffic statistics in road net- works, but also the micro-scoped mobility of individual vehicle trajectories. This paper addresses the importance of vehicle trajectory in the design of multihop vehicle-to-infrastructure, infrastructure-to-vehicle, and vehicle-to-vehicle data forwarding schemes. First, we explain the modeling of packet delivery delay and vehicle travel delay in both a road segment and an end-to-end path in a road net- work. Second, we describe a state-of-the-art data forwarding scheme using vehicular traffic statistics for the estimation of the end-to- end delivery delay as a forwarding metric. Last, we describe two data forwarding schemes based on both vehicle trajectory and vehicu- lar traffic statistics in a privacy-preserving manner.
基金Supported by the National Natural Science Foundation of China under Grant Nos 60508011, 60878019, 10821062, 10934001, 60677002 and 10828407, and the National Basic Research Program of China under Grant Nos 2009CB930504, 2007CB307001, 2006CB921601 and 2006CB806007.
文摘Mono- and dual-branched molecules, { 4-[2-（4-benzothiazol-2-yl-phenyl）-vinyl]-phenyl}-（4-methoxy-phenyl）-phenyl- amine （BS1） and bis-{4-[2- （4-benzothiazol-2-yl-phenyl）-vinyI]-phenyl}-（4-methoxy-phenyI）-phenyl-amine （BS2）, are investigated with one- and two-photon static spectroscopy, and the femtosecond fluorescence up-conversion technique. The molecules show branch-based fluorescence emission at low quantum yield. U1trafast non-radiative decay on a picosecond time scale is found and is attributed to intramolecular charge-transfer bridged by the central triphenylamine. The two-photon absorption cross-sections of BS1 and BS2 are 19.1 and 19.4 GM, respectively.
