目的探讨陈旧性子宫壁假道的诊断与预防子宫壁假道的方法。方法 2013年1月-2015年1月该中心行超声联合宫腔镜检查诊断陈旧性子宫壁假道33例,分析其发生原因、超声及宫腔镜下特点。结果 33例患者中子宫壁假道发生在宫颈25例,占75.8%,宫体...目的探讨陈旧性子宫壁假道的诊断与预防子宫壁假道的方法。方法 2013年1月-2015年1月该中心行超声联合宫腔镜检查诊断陈旧性子宫壁假道33例,分析其发生原因、超声及宫腔镜下特点。结果 33例患者中子宫壁假道发生在宫颈25例,占75.8%,宫体8例,其中,子宫过度前屈及后屈84.9%;子宫壁假道长度≤1.5 cm 11例,1.5~3.0 cm 16例,〉3 cm 6例;宫腔完全封闭15例,其中,宫腔镜检查时分离并进入宫腔3例。结论子宫壁假道多发生于宫颈,与子宫体过度屈曲有关,超声引导的宫腔操作可能会减少宫壁假道的发生。展开更多
Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurr...Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF) following in vitro fertilization, 16 women diagnosed with RM and seven recent fathers (control) were examined. Sperm were examined pre- and post-density centrifugation by the sperm chromatin dispersion (SCD) test and the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. There were no significant differences in the age of either partner or sperm concentration, motility or morphology between three groups. Moreover, there were no obvious differences in sperm DNA fragmentation measured by either test. However, whilst on average sperm DNA fragmentation in all groups was statistically lower in prepared sperm when measured by the SCD test, this was not seen with the results from the TUNEL assay. These results do not support the hypothesis that sperm DNA fragmentation is an important cause of RIF or RM, or that sperm DNA integrity testing has value in such patients. It also highlights significant differences between test methodologies and sperm preparation methods in interpreting the data from sperm DNA fragmentation tests.展开更多
The incidence of congenital uterine anomalies(CUA)appears to be higher than previously thought owing to improved diagnostic imaging modalities.[1]A recent systematic review has estimated the prevalence to be 5.5%in th...The incidence of congenital uterine anomalies(CUA)appears to be higher than previously thought owing to improved diagnostic imaging modalities.[1]A recent systematic review has estimated the prevalence to be 5.5%in the unselected population,8.0%in infertile women,and 13.3%in those with a history of miscarriage.The commonest anomaly across all populations appear to be the septate variety(ie,canalization defects)followed by the bicornuate variety(ie,fusion defects).[2]Another meta-analysis has shown that several adverse reproductive outcomes associated with CUA,such as increased miscarriage rates,increased preterm delivery rates,and increased perinatal mortality rates.[3]展开更多
文摘目的探讨陈旧性子宫壁假道的诊断与预防子宫壁假道的方法。方法 2013年1月-2015年1月该中心行超声联合宫腔镜检查诊断陈旧性子宫壁假道33例,分析其发生原因、超声及宫腔镜下特点。结果 33例患者中子宫壁假道发生在宫颈25例,占75.8%,宫体8例,其中,子宫过度前屈及后屈84.9%;子宫壁假道长度≤1.5 cm 11例,1.5~3.0 cm 16例,〉3 cm 6例;宫腔完全封闭15例,其中,宫腔镜检查时分离并进入宫腔3例。结论子宫壁假道多发生于宫颈,与子宫体过度屈曲有关,超声引导的宫腔操作可能会减少宫壁假道的发生。
文摘Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF) following in vitro fertilization, 16 women diagnosed with RM and seven recent fathers (control) were examined. Sperm were examined pre- and post-density centrifugation by the sperm chromatin dispersion (SCD) test and the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. There were no significant differences in the age of either partner or sperm concentration, motility or morphology between three groups. Moreover, there were no obvious differences in sperm DNA fragmentation measured by either test. However, whilst on average sperm DNA fragmentation in all groups was statistically lower in prepared sperm when measured by the SCD test, this was not seen with the results from the TUNEL assay. These results do not support the hypothesis that sperm DNA fragmentation is an important cause of RIF or RM, or that sperm DNA integrity testing has value in such patients. It also highlights significant differences between test methodologies and sperm preparation methods in interpreting the data from sperm DNA fragmentation tests.
文摘The incidence of congenital uterine anomalies(CUA)appears to be higher than previously thought owing to improved diagnostic imaging modalities.[1]A recent systematic review has estimated the prevalence to be 5.5%in the unselected population,8.0%in infertile women,and 13.3%in those with a history of miscarriage.The commonest anomaly across all populations appear to be the septate variety(ie,canalization defects)followed by the bicornuate variety(ie,fusion defects).[2]Another meta-analysis has shown that several adverse reproductive outcomes associated with CUA,such as increased miscarriage rates,increased preterm delivery rates,and increased perinatal mortality rates.[3]