近年来土壤污染日益严重,现阶段迫切需要研究出高效经济的土壤修复技术来修复污染土壤、实现土壤资源的可持续利用。在此背景下,绿色且环境友好的微生物修复技术具有广阔的发展前景。为了解土壤微生物修复领域的研究状况、研究重点和发...近年来土壤污染日益严重,现阶段迫切需要研究出高效经济的土壤修复技术来修复污染土壤、实现土壤资源的可持续利用。在此背景下,绿色且环境友好的微生物修复技术具有广阔的发展前景。为了解土壤微生物修复领域的研究状况、研究重点和发展趋势,采用Web of Science数据库对2001年1月~2020年5月该领域的6171篇文章进行了文献计量研究和可视化处理。分析结果表明:土壤微生物修复领域在全世界的重视程度逐渐升高,发展态势较好,且未来会进一步得到重视。欧洲国家土壤微生物修复研究开展的较早,发展中国家正在成为研究主力。对关键词进行分析可知,重金属污染的修复、微生物群落结构的变化、环境因素的控制和降解机理的探索是修复研究关注的热点。土壤微生物修复与其他修复技术联用可以收到更好的修复效果,这也已成为今后的重要发展趋势。展开更多
Background Acute-on-chronic hepatitis B liver failure （ACLF-HBV） is a clinically severe disease associated with major life-threatening complications including hepatic encephalopathy and hepatorenal syndrome. The aim...Background Acute-on-chronic hepatitis B liver failure （ACLF-HBV） is a clinically severe disease associated with major life-threatening complications including hepatic encephalopathy and hepatorenal syndrome. The aim of this study was to evaluate the short-term prognostic predictability of the model for end-stage liver disease （MELD）, MELD-based indices, and their dynamic changes in patients with ACLF-HBV, and to establish a new model for predicting the prognosis of ACLF-HBV. Methods A total of 172 patients with ACLF-HBV who stayed in the hospital for more than 2 weeks were retrospectively recruited. The predictive accuracy of MELD, MELD-based indices, and their dynamic change （A） were compared using the area under the receiver operating characteristic curve method. The associations between mortality and patient characteristics were studied by univariate and multivariate analyses. Results The 3-month mortality was 43.6%. The largest concordance （c） statistic predicting 3-month mortality was the MELD score at the end of 2 weeks of admission （0.8）, followed by the MELD：sodium ratio （MESO） （0.796） and integrated MELD （iMELD） （0.758） scores, AMELD （0.752）, AMESO （0.729）, and MELD plus sodium （MELD-Na） （0.728） scores. In multivariate Logistic regression analysis, the independent factors predicting prognosis were hepatic encephalopathy （OR=3.466）, serum creatinine, international normalized ratio （INR）, and total bilirubin at the end of 2 weeks of admission （OR=10.302, 6.063, 5.208, respectively）, and cholinesterase on admission （OR=0.255）. This regression model had a greater prognostic value （c=0.85, 95% CI 0.791-0.909） compared to the MELD score at the end of 2 weeks of admission （Z=4.9851, P=0.0256）. Conclusions MELD score at the end of 2 weeks of admission is a useful predictor for 3-month mortality in ACLF-HBV patients. Hepatic encephalopathy, serum creatinine, international normalized ratio, and total bilirubin at the end of 2 weeks of admission and cholinesterase on admission are independent predictors of 3-month mortality.展开更多
文摘近年来土壤污染日益严重,现阶段迫切需要研究出高效经济的土壤修复技术来修复污染土壤、实现土壤资源的可持续利用。在此背景下,绿色且环境友好的微生物修复技术具有广阔的发展前景。为了解土壤微生物修复领域的研究状况、研究重点和发展趋势,采用Web of Science数据库对2001年1月~2020年5月该领域的6171篇文章进行了文献计量研究和可视化处理。分析结果表明:土壤微生物修复领域在全世界的重视程度逐渐升高,发展态势较好,且未来会进一步得到重视。欧洲国家土壤微生物修复研究开展的较早,发展中国家正在成为研究主力。对关键词进行分析可知,重金属污染的修复、微生物群落结构的变化、环境因素的控制和降解机理的探索是修复研究关注的热点。土壤微生物修复与其他修复技术联用可以收到更好的修复效果,这也已成为今后的重要发展趋势。
文摘Background Acute-on-chronic hepatitis B liver failure （ACLF-HBV） is a clinically severe disease associated with major life-threatening complications including hepatic encephalopathy and hepatorenal syndrome. The aim of this study was to evaluate the short-term prognostic predictability of the model for end-stage liver disease （MELD）, MELD-based indices, and their dynamic changes in patients with ACLF-HBV, and to establish a new model for predicting the prognosis of ACLF-HBV. Methods A total of 172 patients with ACLF-HBV who stayed in the hospital for more than 2 weeks were retrospectively recruited. The predictive accuracy of MELD, MELD-based indices, and their dynamic change （A） were compared using the area under the receiver operating characteristic curve method. The associations between mortality and patient characteristics were studied by univariate and multivariate analyses. Results The 3-month mortality was 43.6%. The largest concordance （c） statistic predicting 3-month mortality was the MELD score at the end of 2 weeks of admission （0.8）, followed by the MELD：sodium ratio （MESO） （0.796） and integrated MELD （iMELD） （0.758） scores, AMELD （0.752）, AMESO （0.729）, and MELD plus sodium （MELD-Na） （0.728） scores. In multivariate Logistic regression analysis, the independent factors predicting prognosis were hepatic encephalopathy （OR=3.466）, serum creatinine, international normalized ratio （INR）, and total bilirubin at the end of 2 weeks of admission （OR=10.302, 6.063, 5.208, respectively）, and cholinesterase on admission （OR=0.255）. This regression model had a greater prognostic value （c=0.85, 95% CI 0.791-0.909） compared to the MELD score at the end of 2 weeks of admission （Z=4.9851, P=0.0256）. Conclusions MELD score at the end of 2 weeks of admission is a useful predictor for 3-month mortality in ACLF-HBV patients. Hepatic encephalopathy, serum creatinine, international normalized ratio, and total bilirubin at the end of 2 weeks of admission and cholinesterase on admission are independent predictors of 3-month mortality.
