目的探讨感染新型冠状病毒肺炎(COVID-19)儿童的临床特征及药物治疗情况,为临床诊治提供经验。方法通过检索中国知网(CNKI)、中华医学期刊网、维普数据库、万方数据库、Web of Science、PubMed的COVID-19儿童相关病例报告,对患儿疾病流...目的探讨感染新型冠状病毒肺炎(COVID-19)儿童的临床特征及药物治疗情况,为临床诊治提供经验。方法通过检索中国知网(CNKI)、中华医学期刊网、维普数据库、万方数据库、Web of Science、PubMed的COVID-19儿童相关病例报告,对患儿疾病流行病学调查情况、药物治疗及其治疗结局进行汇总性分析。结果共收集到COVID-19 患儿43例,男、女性各26、17例,年龄36 h^15岁,家庭聚集性发病及密切接触史占83.7%。患儿的临床表现以呼吸道疾病、胃肠道疾病多见,以发热、咳嗽、腹泻为主,最早出现在感染后2 d,最晚为感染后17 d。接受抗病毒药物者38例,34例经干扰素治疗的患儿未出现明显不良反应,2例患儿使用洛匹那韦/利托那韦出现胃肠道不良反应后停药。43例患儿中34例患儿的临床结局改善,9例痊愈,其中22例新型冠状病毒核酸阳转阴。结论 COVID-19感染患儿临床症状普遍较轻,流行病学史以聚集性发病为主,对症治疗与抗病毒治疗有一定的疗效。展开更多
OBJECTIVE Recently,some reports show that curcuma has a good curative effect on the treatment of psoriasis;while curcuma has many components,so the present study was designed to investigate the effective parts of curc...OBJECTIVE Recently,some reports show that curcuma has a good curative effect on the treatment of psoriasis;while curcuma has many components,so the present study was designed to investigate the effective parts of curcuma on treatment of psoriasis,in addition,we will explore the mechanisms of curcuma therapeutic effect.METHODS First,we observed that curcuma′s extractions effect on mitosis of mouse vaginal epithelial cells;then psoriasis like was induced by wiping imiquimod in the surface of the binaural dorsal skin of the animal,the score of skin damage was measured on days 7 and 14;in order to explore the mechanisms of curcuma’s extractions on psoriasis,immune factors expression(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was determined in propranolol induced psoriasis like.RESULTS Curcuma′s extraction prohibited the mitosis of mouse vaginal epithelial cells;curcuma’s extractions produced a significant and dose dependent inhibition of psoriasis during the entire duration of the study in imiquimod induced psoriasis like;and the expression of immune factors(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was also found to be less in the curcuma′s extraction treated group as compared to control.CONCLUSION We believe that the curative effectof curcuma’sextraction may due to its inhibition effect on the expression of immune factors.Our results contribute towards validation of curcuma in the treatment of psoriasis and other joint disorders.展开更多
文摘OBJECTIVE Recently,some reports show that curcuma has a good curative effect on the treatment of psoriasis;while curcuma has many components,so the present study was designed to investigate the effective parts of curcuma on treatment of psoriasis,in addition,we will explore the mechanisms of curcuma therapeutic effect.METHODS First,we observed that curcuma′s extractions effect on mitosis of mouse vaginal epithelial cells;then psoriasis like was induced by wiping imiquimod in the surface of the binaural dorsal skin of the animal,the score of skin damage was measured on days 7 and 14;in order to explore the mechanisms of curcuma’s extractions on psoriasis,immune factors expression(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was determined in propranolol induced psoriasis like.RESULTS Curcuma′s extraction prohibited the mitosis of mouse vaginal epithelial cells;curcuma’s extractions produced a significant and dose dependent inhibition of psoriasis during the entire duration of the study in imiquimod induced psoriasis like;and the expression of immune factors(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was also found to be less in the curcuma′s extraction treated group as compared to control.CONCLUSION We believe that the curative effectof curcuma’sextraction may due to its inhibition effect on the expression of immune factors.Our results contribute towards validation of curcuma in the treatment of psoriasis and other joint disorders.
