A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block,China.The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using re...A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block,China.The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves.The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions.Our results reveal complex seismic phases in the Liupanshan area,implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block.The average crustal thickness is 51.5 km in the northeast Tibetan Plateau,53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block,resulting in a concave Moho beneath the Liupan Mountain.The Poisson's ratio of the Liupanshan area varies between 0.27-0.29,higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain,suggesting partial melting in the lower crust.The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties,which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision.展开更多
OBJECTIVE:To investigate the protective effects of Zuogui Wan(左归丸,ZGW)on bone loss induced by ovariectomy(OVX)and its mechanism via orexin-A and orexin receptors in the osteoporosis rat model.METHODS:Fifty Sprague-...OBJECTIVE:To investigate the protective effects of Zuogui Wan(左归丸,ZGW)on bone loss induced by ovariectomy(OVX)and its mechanism via orexin-A and orexin receptors in the osteoporosis rat model.METHODS:Fifty Sprague-Dawley female rats were randomly divided into sham-operated(sham)group and four OVX subgroups.Rats subjected to sham and OVX were treated with the vehicle(OVX,1 mL/100 g weight,n=10),17β-estradiol(E2,50μg·kg-1·d-1),and ZGW at the doses of 2.3(ZGW-L)and 4.6(ZGW-H)g/kg/day lyophilized powder daily for 3 months,respectively.The serum biochemical parameters of 17β-estrogen(17β-E2),tartrate-resistant acid phosphatase(TRACP-5 b)and bone alkaline phosphatase(BALP)were measured by enzyme-linked immunosorbent assay.Hematoxylin-eosin staining was used to detect the changes in the morphological structure in bones.Microcomputed tomography was used to evaluate the bone mineral density and microarchitecture of the distal femur.The gene or protein expression of orexin-A,orexin receptor 1(OX1R),orexin receptor 2(OX2R),osteoprotegerin(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)were assayed by either quantitative polymerase chain reaction or Western blot analysis.RESULTS:Compared with the OVX group,ZGW could reduce the serum level of TRACP-5b and increased the serum levels of BALP and 17β-E2(P<0.01).Meanwhile,ZGW could prevent bone loss and improved bone trabecular microarchitecture by increasing the trabeculae structure thickness and trabecular number,and arranging the trabeculae structure properly.Compared with the OVX group,it was upregulated for the orexin-A and OX2R mRNA or protein expression from the hypothalamus and tibiae,and OPG in the tibiae of ZGW groups(P<0.01,<0.05),while downregulated for the OX1R mRNA and protein expression in the tibiae and hypothalamus and RANKL from the tibiae(P<0.01).CONCLUSION:ZGW exhibited a protective effect for PMOP that may be mediated via orexin-A and orexin receptors regulation.展开更多
基金Supperted by the National Basic Research Program of China(Grant No.2003CB214607)the National Natural Science Foundation of China(Grant No.40574015)SRFDP(Grant No.20050284040)
文摘A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block,China.The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves.The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions.Our results reveal complex seismic phases in the Liupanshan area,implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block.The average crustal thickness is 51.5 km in the northeast Tibetan Plateau,53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block,resulting in a concave Moho beneath the Liupan Mountain.The Poisson's ratio of the Liupanshan area varies between 0.27-0.29,higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain,suggesting partial melting in the lower crust.The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties,which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision.
基金Supported by Traditional Chinese and Western Medicine Clinical Medicine Brand Construction Project of Jiangsu Higher Education Institutions(PhaseⅡ)National Natural Science Foundation of China(No.81573874 and81873229)。
文摘OBJECTIVE:To investigate the protective effects of Zuogui Wan(左归丸,ZGW)on bone loss induced by ovariectomy(OVX)and its mechanism via orexin-A and orexin receptors in the osteoporosis rat model.METHODS:Fifty Sprague-Dawley female rats were randomly divided into sham-operated(sham)group and four OVX subgroups.Rats subjected to sham and OVX were treated with the vehicle(OVX,1 mL/100 g weight,n=10),17β-estradiol(E2,50μg·kg-1·d-1),and ZGW at the doses of 2.3(ZGW-L)and 4.6(ZGW-H)g/kg/day lyophilized powder daily for 3 months,respectively.The serum biochemical parameters of 17β-estrogen(17β-E2),tartrate-resistant acid phosphatase(TRACP-5 b)and bone alkaline phosphatase(BALP)were measured by enzyme-linked immunosorbent assay.Hematoxylin-eosin staining was used to detect the changes in the morphological structure in bones.Microcomputed tomography was used to evaluate the bone mineral density and microarchitecture of the distal femur.The gene or protein expression of orexin-A,orexin receptor 1(OX1R),orexin receptor 2(OX2R),osteoprotegerin(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)were assayed by either quantitative polymerase chain reaction or Western blot analysis.RESULTS:Compared with the OVX group,ZGW could reduce the serum level of TRACP-5b and increased the serum levels of BALP and 17β-E2(P<0.01).Meanwhile,ZGW could prevent bone loss and improved bone trabecular microarchitecture by increasing the trabeculae structure thickness and trabecular number,and arranging the trabeculae structure properly.Compared with the OVX group,it was upregulated for the orexin-A and OX2R mRNA or protein expression from the hypothalamus and tibiae,and OPG in the tibiae of ZGW groups(P<0.01,<0.05),while downregulated for the OX1R mRNA and protein expression in the tibiae and hypothalamus and RANKL from the tibiae(P<0.01).CONCLUSION:ZGW exhibited a protective effect for PMOP that may be mediated via orexin-A and orexin receptors regulation.
