冠心病心绞痛患者给予扶阳益气汤联合倍他乐克治疗的临床研究

目的:探究冠心病心绞痛患者给予扶阳益气汤联合倍他乐克治疗的临床效果。方法:本研究选取2017年11月-2018年11月就诊的70例冠心病心绞痛患者作为研究的对象,以抽取双色球的方式将患者分为对照组(n=35)和研究组(n=35),对照组使用西药倍他乐克进行治疗,研究组使用扶阳益气汤联合倍他乐克治疗,比较两组治疗有效率、血清炎症因子水平及不良反应情况。结果:研究组治疗有效率(94.29%)明显优于对照组(68.57%);研究组血清炎症因子水平(肿瘤坏死因子、超敏C-反应蛋白、白细胞介素6)明显优于对照组;研究组不良反应发生率(2.86%)明显少于对照组(20.00%),差异均有统计学意义(P<0.05)。结论:冠心病心绞痛患者给予扶阳益气汤联合倍他乐克治疗的临床效果显著,能帮助调节患者的血清炎症因子水平,在提高治疗有效率的同时降低了不良反应发生率。

Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial

OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19.Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization.The patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 weeks.The improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two groups.RESULTS:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.